SynthesisJournal of neuro-oncology2022
Bone metastasis from glioblastoma: a systematic review.
Synthesis in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Extracranial Metastases in Glioblastoma, IDH-Wildtype: A Case Series.Diagnostics (Basel, Switzerland) · 2026Article
- Primary glioblastoma with spontaneous transdural invasion and contiguous calvarial/mastoid osteolysis: a case report and literature review.Frontiers in surgery · 2026Article
- Diffuse bone-marrow metastasis of grade 4 isocitrate dehydrogenase-mutant astrocytoma associated with hematological abnormalities: Gliomatosis of the bone marrow.Surgical neurology international · 2025Article
- Late spinal metastasis of glioblastoma multiforme after maximal tumor resection: A case report.Surgical neurology international · 2025Article
- Extraneural metastases of glioblastoma: A case report and literature review.Surgical neurology international · 2025Article
- A Rare Case of Glioblastoma with Osseous Metastases.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2024Article
- CD13 expression affects glioma patient survival and influences key functions of human glioblastoma cell lines in vitro.BMC cancer · 2024Article
- Breaking boundaries: A rare case of glioblastoma with uncommon extraneural metastases: A case report and literature review.Brain & spine · 2024Article
- Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.Cancer reports (Hoboken, N.J.) · 2023Review
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- Article
- Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management.Diagnostics (Basel, Switzerland) · 2023Review
- Review
- Primary thoracic intramedullary spinal cord tumor with likely metastases of glial origin to the lumbosacral vertebrae: Illustrative case.Surgical neurology international · 2023Article
- Recurrent glioblastoma metastatic to the lumbar vertebra: A case report and literature review: Surgical oncology.Frontiers in oncology · 2023Article
- Glioblastoma: an organ-confined disease?Translational cancer research · 2022Article
- Pediatric-type diffuse high-grade glioma with systemic metastasis: A case report.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
introductionGlioblastoma (GBM) is a devastating disease with poor overall survival. Despite the common occurrence of GBM among primary brain tumors, metastatic disease is rare. Our goal was to perform a systematic literature review on GBM with osseous metastases and understand the rate of metastasis to the vertebral column as compared to the remainder of the skeleton, and how this histology would fit into our current paradigm of treatment for bone metastases.
methodsA Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant literature search was performed using the PubMed database from 1952 to 2021. Search terms included "GBM", "glioblastoma", "high-grade glioma", "bone metastasis", and "bone metastases".
resultsOf 659 studies initially identified, 67 articles were included in the current review. From these 67 articles, a total of 92 distinct patient case presentations of metastatic glioblastoma to bone were identified. Of these cases, 58 (63%) involved the vertebral column while the remainder involved lesions within the skull, sternum, rib cage, and appendicular skeleton.
conclusionMetastatic dissemination of GBM to bone occurs. While the true incidence is unknown, workup for metastatic disease, especially involving the spinal column, is warranted in symptomatic patients. Lastly, management of patients with GBM vertebral column metastases can follow the International Spine Oncology Consortium two-step multidisciplinary algorithm for the management of spinal metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.