Evidence map›Paper›PMID 35578036›Full record

ArticleParasitology research2022

Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity.

Hardo Suzy Donfack Chouna, Darline Dize, Donald Ulrich Kenou Kagho, Jean Jules Kezetas Bankeu, Yannick Stéphane Fotsing Fongang, Mariscal Brice Tchatat Tali, Beaudelaire Kemvoufo Ponou, Gabin Thierry Mbahbou Bitchagno, Angelbert Fusi Awantu, Léon Azefack Tapondjou and 4 more

Abstract read
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In one paragraph

Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hardo Suzy Donfack ChounaDepartment of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Darline DizeDepartment of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box: 812, Yaoundé, Cameroon.
Donald Ulrich Kenou KaghoDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Jean Jules Kezetas BankeuDepartment of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon.
Yannick Stéphane Fotsing FongangDepartment of Chemistry, Higher Teachers Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon.
Mariscal Brice Tchatat TaliDepartment of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box: 812, Yaoundé, Cameroon.
Beaudelaire Kemvoufo PonouDepartment of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon. beaudelaireponou@yahoo.fr.ORCID http://orcid.org/0000-0002-7606-8373
Gabin Thierry Mbahbou BitchagnoDepartment of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Angelbert Fusi AwantuDepartment of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon.
Léon Azefack TapondjouDepartment of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Bruno Ndjakou LentaDepartment of Chemistry, Higher Teachers Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon. lentabruno@yahoo.fr.
Fabrice Boyom FekamDepartment of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box: 812, Yaoundé, Cameroon.
Norbert SewaldOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501, Bielefeld, Germany.
Silvère Augustin NgouelaDepartment of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.

Funding

Deutscher Akademischer Austauschdienst YaBiNaPA project no. 57316173
6 · The paper itself

Abstract

Ripe figs, barks, and wood of Ficus vallis-choudae are used in traditional medicine against several conditions including nausea and malaria. However, its use is still to be scientifically documented and validated. Hence, the aim of the present work was to evaluate the antiplasmodial activity of the dichloromethane-methanol (DCM-MeOH (1:1)) crude extract, their hexane, dichloromethane, ethyl acetate, and methanoli fractions, as well as the isolated chemical constituents. The chemical study of the DCM-MeOH (1:1) crude extract of F. vallis-choudae figs led to the isolation of fifteen (15) known compounds identified based on their spectroscopic data [one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), mass spectrometry] and by comparison of these data with those reported in the literature. Some of the isolated compounds were assessed in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-sensitive 3D7 (Pf3D7) and multidrug-resistant Dd2 strains. The dichloromethane fraction exhibited very good antiplasmodial activity against both strains with IC

Indexed as

AntimalarialsFicusMalariaMalaria, FalciparumMethanolMethylene ChloridePlant ExtractsPlasmodium falciparumAntimalarialsMethanolMethylene ChloridePlant ExtractsAntiplasmodial activityChemical constituentsFicus vallis-choudaeMoraceaePlasmodium falciparumWighteone

Identifiers

PMID35578036
PMCPMC9110216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.