ArticleNature communications2022
Cooperative regulation of PBI1 and MAPKs controls WRKY45 transcription factor in rice immunity.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 65 citations in OpenAlex.
- Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A β-1,3-glucanase antagonizes a phase-separating WRKY repressor to confer saline-alkaline tolerance in rice.The New phytologist · 2026Article
- Comprehensive Profiling of the RicePlants (Basel, Switzerland) · 2026Article
- The C2H2-type zinc finger protein ZOS202 regulates leaf senescence in rice by targeting senescence-associated transcription factors and ROS homoeostasis.The Plant journal : for cell and molecular biology · 2026Article
- Jasmonate regulates male sterility in cucumber.aBIOTECH · 2026Article
- Silicon Enhances Rice Tolerance to Drought and Blast Disease Through Modulating ROS Accumulation and Stress-Related Genes.Plants (Basel, Switzerland) · 2026Article
- Molecular Insights into the Role ofPlants (Basel, Switzerland) · 2026Article
- Ubiquitination modifications as central regulators of metabolic dysfunction in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Review
- Natural variation in PtobZIP18 confers the trade-off between stem growth and drought tolerance in Populus.Plant biotechnology journal · 2025Article
- WRKYs as regulatory hubs of secondary metabolic networks: Diverse inducers and distinct responses.Plant communications · 2025Review
- Research Progress on Rice-Blast-Resistance-Related Genes.Plants (Basel, Switzerland) · 2025Review
- Genome-Wide Identification, Characterization, and Expression Analysis of the U-Box Gene Family in Cucumber (Plants (Basel, Switzerland) · 2025Article
- Nei 6 You 7075, a hybrid rice cultivar, exhibits enhanced disease resistance and drought tolerance traits.BMC plant biology · 2024Article
- Rice E3 ubiquitin ligases: From key modulators of host immunity to potential breeding applications.Plant communications · 2024Review
- Use of CRISPR Technology in Gene Editing for Tolerance to Biotic Factors in Plants: A Systematic Review.Current issues in molecular biology · 2024Review
- Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance.Plant biotechnology journal · 2024Review
- KIN10-mediated HB16 protein phosphorylation and self-association improve cassava disease resistance by transcriptional activation of lignin biosynthesis genes.Plant biotechnology journal · 2024Article
- Proteolysis in plant immunity.The Plant cell · 2024Review
- Review
- JrPHL8-JrWRKY4-JrSTH2L module regulates resistance toHorticulture research · 2024Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The U-box type ubiquitin ligase PUB44 positively regulates pattern-triggered immunity in rice. Here, we identify PBI1, a protein that interacts with PUB44. Crystal structure analysis indicates that PBI1 forms a four-helix bundle structure. PBI1 also interacts with WRKY45, a master transcriptional activator of rice immunity, and negatively regulates its activity. PBI1 is degraded upon perception of chitin, and this is suppressed by silencing of PUB44 or expression of XopP, indicating that PBI1 degradation depends on PUB44. These data suggest that PBI1 suppresses WRKY45 activity when cells are in an unelicited state, and during chitin signaling, PUB44-mediated degradation of PBI1 leads to activation of WRKY45. In addition, chitin-induced MAP kinase activation is required for WRKY45 activation and PBI1 degradation. These results demonstrate that chitin-induced activation of WRKY45 is regulated by the cooperation between MAP kinase-mediated phosphorylation and PUB44-mediated PBI1 degradation.
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