Evidence map›Paper›PMID 35577780›Full record

ArticleLight, science & applications2022

Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy.

Xiaoyi Zhu, Qiang Huang, Anthony DiSpirito, Tri Vu, Qiangzhou Rong, Xiaorui Peng, Huaxin Sheng, Xiling Shen, Qifa Zhou, Laiming Jiang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Light, science & applications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 155 citations in OpenAlex.

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  5. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Xiaoyi ZhuDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID http://orcid.org/0000-0003-4738-0779
Qiang HuangDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Anthony DiSpiritoDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Tri VuDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Qiangzhou RongDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID http://orcid.org/0000-0002-7549-9278
Xiaorui PengDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Huaxin ShengRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Xiling ShenDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Qifa ZhouRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Laiming JiangRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. laiming_jiang@foxmail.com.
Ulrike HoffmannDepartment of Anesthesiology, Duke University, Durham, NC, 27708, USA. ulrike.hoffmann@duke.edu.
Junjie YaoDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA. junjie.yao@duke.edu.ORCID http://orcid.org/0000-0002-2381-706X
Duke University · USUniversity of Southern California · US

Funding

High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic StrokeR01NS111039 · NINDS · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2023
$2.7M
Whole-organ bioreactor with integrated nondestructive 3D molecular imagingR44HL138185 · NHLBI · SONOVOL, INC. · PI CZERNUSZEWICZ, TOMASZ JOSEPH, GESSNER, RYAN · 2017 to 2020
$2.2M
Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving AnimalsRF1NS115581 · NINDS · DUKE UNIVERSITY · PI VERKHUSHA, VLADISLAV, YAO, JUNJIE · 2020 to 2020
$2.0M
High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Transcranial Photoacoustic Imaging Using a Virtual ArrayR21EB027981 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI JING, YUN · 2020 to 2020
$455k
Photoacoustic-imaging-guided intravascular sonothrombolysisR21EB027304 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI JIANG, XIAONING, YAO, JUNJIE · 2019 to 2020
$411k
A turnkey research platform to accelerate clinical translation of focused-ultrasound (FUS) oncology therapiesR43CA239830 · NCI · SONOVOL, INC. · PI GESSNER, RYAN · 2019 to 2019
$300k
Development of a Longitudinal Molecular Imaging Platform to Support Immuno-Oncology ResearchR43CA243822 · NCI · SONOVOL, INC. · PI GESSNER, RYAN · 2019 to 2019
$244k
NCI NIH HHS R43 CA239830NCI NIH HHS R43 CA243822NHLBI NIH HHS R44 HL138185NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB027304NIBIB NIH HHS R21 EB027981NINDS NIH HHS R01 NS111039NINDS NIH HHS RF1 NS115581
6 · The paper itself

Abstract

High-speed high-resolution imaging of the whole-brain hemodynamics is critically important to facilitating neurovascular research. High imaging speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks, and tracking fast pathophysiological activities at the microvessel level, which will enable advances in current queries in neurovascular and brain metabolism research, including stroke, dementia, and acute brain injury. Further, real-time imaging of oxygen saturation of hemoglobin (sO

Identifiers

PMID35577780
PMCPMC9110749
OpenAlexW4280519662

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.