Evidence map›Paper›PMID 35577626›Full record

ReviewBlood reviews2022

No apparent association between mRNA COVID-19 vaccination and venous thromboembolism.

Matthew Nicholson, Hadi Goubran, Noel Chan, Deborah Siegal

Open access · hybridAbstract readReview
In one paragraph

Review in Blood reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Vasectomy in the absence of paternity A pre- and post-pandemic Canadian cohort analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
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  14. Portal vein thrombosis after second Pfizer/BioNTech coronavirus disease 2019 vaccine.Journal of vascular surgery cases and innovative techniques · 2022
    Article
  15. Platelet and extracellular vesicles in COVID-19 infection and its vaccines.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Matthew NicholsonSaskatoon Cancer Center, Saskatchewan Cancer Agency, and College of Medicine, University of Saskatchewan, SK, Canada. Electronic address: matthew.nicholson@saskcancer.ca.
Hadi GoubranSaskatoon Cancer Center, Saskatchewan Cancer Agency, and College of Medicine, University of Saskatchewan, SK, Canada.
Noel ChanDivision of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Deborah SiegalDivision of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
University of Saskatchewan · CAMcMaster University · CAOttawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By January 2022 over ten billion doses of COVID-19 vaccines had been administered worldwide. Concerns about COVID-19 vaccine-associated thrombosis arose after the characterization of a rare prothrombotic condition associated with adenoviral vector-based COVID-19 vaccines known as vaccine-induced immune thrombotic thrombocytopenia (VITT). Although mRNA COVID-19 vaccines have not been linked to VITT, concerns about thrombosis after vaccination persist despite safety data from hundreds of millions of recipients of mRNA COVID-19 vaccines. With widespread vaccination some VTE will occur shortly after vaccination by chance alone because VTE is a common condition that affects 1 to 2 in 1000 persons each year. Detailed analysis is required to determine whether these VTE events are coincidental or associated when they occur in close proximity to mRNA vaccine administration. This paper will review what is currently known about rates of VTE after mRNA vaccination in adults, discuss the reasons why uncertainty on this topic persists, and briefly review the implications of these findings for clinical practice and health policy.

Indexed as

COVID-19Purpura, Thrombocytopenic, IdiopathicVaccinesVenous ThromboembolismAdultCOVID-19 VaccinesHumansmRNA VaccinesRNA, MessengerVaccinationCOVID-19 VaccinesmRNA VaccinesRNA, MessengerVaccinesBNT162b2COVID-19ModernamRNA-1273PfizerVTE

Identifiers

PMID35577626
PMCPMC9091073
OpenAlexW4280505772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.