ArticleAtherosclerosis2022
Suboptimal HIV suppression is associated with progression of coronary artery stenosis: The Multicenter AIDS Cohort Study (MACS) longitudinal coronary CT angiography study.
Article in Atherosclerosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Better Longitudinal Adherence to Antiretroviral Therapy Among Virally Suppressed People With HIV Is Associated With Reduced Occurrence of Serious Non-AIDS Events.Open forum infectious diseases · 2026Trial
- Combining Observational Studies to Reduce Multiple Biases.Epidemiology (Cambridge, Mass.) · 2026Article
- Lipoprotein(a) is associated with coronary inflammation in people with HIV and undetectable HIV RNA.European heart journal. Imaging methods and practice · 2026Article
- Differential Performance of Polygenic Score for Coronary Artery Disease Based on Coronary Artery Calcium Between Men Living With and Without HIV.Journal of the American Heart Association · 2025Article
- Coronary artery stenosis in Japanese hemophiliacs living with HIV-1 progressed dramatically over two years.Global health & medicine · 2025Article
- Comparative 10-year atherosclerotic cardiovascular disease risk in Ethiopian HIV patients on first-line versus second-line combined antiretroviral therapy.Atherosclerosis plus · 2025Article
- Associations between HIV serostatus and coronary artery plaque volume progression.AIDS (London, England) · 2025Observational
- Coronary artery calcium and all-cause mortality in the Multicenter AIDS Cohort Study.Atherosclerosis · 2025Observational
- Viremia Does Not Independently Predict Cardiovascular Disease in People With HIV: A RESPOND Cohort Study.Open forum infectious diseases · 2025Article
- Transgender Women With Suppressed Testosterone Display Lower Burden of Coronary Disease Than Matched Cisgender Men.Journal of the Endocrine Society · 2024Article
- Factors associated with voluntary HIV counseling and testing among young students engaging in casual sexual activity: a cross-sectional study from Eastern China.BMC public health · 2024Article
- High Incidence Rate of Computed Tomography-Measured Steatotic Liver Disease in Men With and Without HIV Infection.The American journal of gastroenterology · 2024Article
- Low Level Viremia Is Associated With Serious non-AIDS Events in People With HIV.Open forum infectious diseases · 2024Article
- Cardiovascular Risk in People Living with Human Immunodeficiency (HIV) Viremia Suppression in a Young, Mid-Eastern European Population - Preliminary Study.Vascular health and risk management · 2024Article
- Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals.American journal of physiology. Heart and circulatory physiology · 2023Article
- Factors associated with coronary artery disease among people living with human immunodeficiency virus: Results from the Colombian HIV/AIDS registry.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- Beyond Undetectable: Modeling the Clinical Benefit of Improved Antiretroviral Adherence in Persons With Human Immunodeficiency Virus With Virologic Suppression.Open forum infectious diseases · 2023Article
- Cumulative exposure to viremia: Methods for the implementation of standardized variables in longitudinal HIV studies.MethodsX · 2023Article
- CARDIOVASCULAR DISEASE IN HIV.Transactions of the American Clinical and Climatological Association · 2022Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsPeople living with HIV (HIV+) are surviving longer due to effective antiretroviral therapy. Cardiovascular disease is a leading cause of non-AIDS related clinical events. We determined HIV-related factors associated with coronary artery stenosis progression.
methodsWe performed serial coronary CT angiography among HIV+ and HIV-uninfected (HIV-) men in the Multicenter AIDS Cohort Study. The median inter-scan interval was 4.5 years. Stenosis was graded as 0, 1-29, 30-49, 50-69 or ≥70%. Progression was defined as an increase ≥2 categories. Suppressed HIV infection was consistent viral loads <50 copies/mL allowing 1 "blip" <500 copies/mL, otherwise considered viremic. Multivariable Poisson regression analysis assessed adjusted associations between HIV serostatus and viremia with coronary stenosis progression.
resultsThe sample included 310 HIV+ (31% viremic) and 234 HIV- men. The median age was 53 years, 30% Black and 23% current smokers. Viremic men were 2.3 times more likely to develop coronary stenosis progression than HIV- men (adjusted RR 2.30; 95% CI, 1.32-4.00, p = 0.003), with no difference in progression between HIV+ suppressed and HIV- men (RR 1.10; 95% CI, 0.70-1.74, p = 0.67). There was a progressive increase in adjusted relative risk with greater viremia (p = 0.03). Men with >1 viral load >500 copies/ml demonstrated greatest stenosis progression (RR 3.01; 95% CI, 1.53-4.92, p = 0.001 compared with HIV- men). Suppressed HIV+ men with suboptimal antiretroviral adherence had greater stenosis progression (RR 1.91; 95% CI 1.12-3.24, p = 0.02) than HIV + suppressed men with optimal adherence.
conclusionsCoronary artery stenosis progression was associated with suboptimal HIV RNA suppression and antiretroviral therapy adherence. Effective ongoing HIV virologic suppression and antiretroviral therapy adherence may mitigate risk for coronary disease events among people living with HIV.
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