ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Cortico-Striatal Activity Characterizes Human Safety Learning via Pavlovian Conditioned Inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis.Cognition · 2026Article
- Pavlovian safety learning: An integrative theoretical review.Psychonomic bulletin & review · 2025Review
- Event Segmentation Promotes the Reorganization of Emotional Memory.Journal of cognitive neuroscience · 2025Article
- Subregions in the ventromedial prefrontal cortex integrate threat and protective information to meta-represent safety.PLoS biology · 2025Article
- Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease.Molecular psychiatry · 2024Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Adaptive Safety Coding in the Prefrontal Cortex.bioRxiv : the preprint server for biology · 2024Article
- Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults.Biological psychiatry global open science · 2024Article
- Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure.Neurobiology of stress · 2022Article
- Pattern separation of fear extinction memory.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Safety learning generates associative links between neutral stimuli and the absence of threat, promoting the inhibition of fear and security-seeking behaviors. Precisely how safety learning is mediated at the level of underlying brain systems, particularly in humans, remains unclear. Here, we integrated a novel Pavlovian conditioned inhibition task with ultra-high field (7 Tesla) fMRI to examine the neural basis of safety learning in 49 healthy participants. In our task, participants were conditioned to two safety signals: a conditioned inhibitor that predicted threat omission when paired with a known threat signal (A+/AX-), and a standard safety signal that generally predicted threat omission (BC-). Both safety signals evoked equivalent autonomic and subjective learning responses but diverged strongly in terms of underlying brain activation (
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