ArticleAnnals of the rheumatic diseases2022
Rising incidence and prevalence of systemic lupus erythematosus: a population-based study over four decades.
Article in Annals of the rheumatic diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mortality and survival in patients with systemic lupus erythematosus in the Middle East and North Africa: a systematic review and meta-analysis.Rheumatology international · 2026Pooled it
- Sex-dependent mechanisms in rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- National Mortality Databases to Assess Disease Burden in Systemic Autoimmune Diseases: A Valuable Resource But With Limitations.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Clinical utility and performance of anti-C1q antibodies for SLE: comparative analysis of three different assays.Lupus science & medicine · 2026Article
- Que sera, rheumatology? Thoughts about the future.Clinical rheumatology · 2026Article
- Prevalence and incidence of systemic lupus erythematosus in Thailand based on national health data.Lupus science & medicine · 2025Article
- Falls Among Individuals With Systemic Lupus Erythematosus: An Observational Study.ACR open rheumatology · 2025Article
- Direction of global health status: a narrative review and recommendation for incorporating integrative medicine for improvement.Journal of medicine and life · 2025Review
- Addressing the challenge of global delays in diagnosis and treatment of systemic lupus erythematosus.Nature reviews. Rheumatology · 2025Review
- Higher PM2.5 exposure increases the risk of incident systemic lupus erythematosus: a prospective cohort study in Taiwan.Lupus science & medicine · 2025Article
- Integrated analysis of polygenic and environmental risk scores for late-onset systemic lupus erythematosus.Journal of autoimmunity · 2025Article
- Review
- Clinical Presentation, Care Pathways, and Delays in Access to Specialized Care in Patients With Systemic Lupus Erythematosus: A Study From Lupus Midwest Network (LUMEN).Arthritis care & research · 2025Article
- Dysregulated Intestinal Host-Microbe Interactions in Systemic Lupus Erythematosus: Insights from Patients and Mouse Models.Microorganisms · 2025Review
- Understanding Sex-biases in Kinetoplastid Infections: Leishmaniasis and Trypanosomiasis.Expert reviews in molecular medicine · 2025Review
- Systemic lupus erythematosus is associated with an increased risk of cervical artery dissection.Scientific reports · 2025Article
- Soluble checkpoint molecules as predictive biomarker for disease activity and long-term outcome in SLE.Frontiers in immunology · 2025Article
- Ultraprocessed Food Intake and Risk of Systemic Lupus Erythematosus Among Women Observed in the Nurses' Health Study Cohorts.Arthritis care & research · 2025Article
- Mapping the spatial and temporal frequency of systemic lupus erythematosus in Brazil.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivesTo determine the trends in incidence, prevalence and mortality of systemic lupus erythematosus (SLE) in a US population over four decades.
methodsWe identified all the patients with SLE in Olmsted County, Minnesota who fulfilled the European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria for SLE during 1976-2018. Age-specific and sex-specific incidence and prevalence rates were adjusted to the standard 2000 projected US population. The EULAR/ACR score was used as a proxy for disease severity. Standardised mortality ratio (SMR) was estimated.
resultsThere were 188 incident SLE cases in 1976-2018 (mean age 46.3±SD 16.9; 83% women). Overall age-adjusted and sex-adjusted annual SLE incidence per 100 000 population was 4.77 (95% CI 4.09 to 5.46). Incidence was higher in women (7.58) than men (1.89). The incidence rate increased from 3.32 during 1976-1988 to 6.44 during 2009-2018. Incidence rates were higher among the racial and ethnic minority populations than non-Hispanic whites. The EULAR/ACR score did not change significantly over time. Overall prevalence increased from 30.6 in 1985 to 97.4 in 2015. During the study period, there was no improvement in SMR over time (p=0.31).
conclusionsThe incidence and prevalence of SLE are increasing in this US population. The increase in incidence may be at least partially explained by the rising ethnic/racial diversity of the population. There was no evidence that the severity of SLE has changed over time. The survival gap between SLE and the general population remains unchanged. As the US population grows more diverse, we might continue to see an increase in the incidence of SLE.
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