Evidence map›Paper›PMID 35577169›Full record

ArticleInternational journal of cardiology2022

The temporal relationships between sleep disturbance and autonomic dysregulation: A co-twin control study.

Minxuan Huang, Donald L Bliwise, Amit Shah, Dayna A Johnson, Gari D Clifford, Martica H Hall, Robert T Krafty, Jack Goldberg, Richard Sloan, Yi-An Ko and 7 more

Open access · greenAbstract readControlled Clinical TrialTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Minxuan HuangDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Donald L BliwiseDepartment of Neurology, School of Medicine, Emory University, Atlanta, GA, USA.
Amit ShahDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine (Cardiology), School of Medicine, Emory University, Atlanta, GA, USA; Atlanta Veteran Affairs Medical Center, Decatur, GA, USA.
Dayna A JohnsonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Gari D CliffordDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Martica H HallDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Robert T KraftyDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Jack GoldbergDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Vietnam Era Twin Registry, Seattle Epidemiologic Research and Information Center, US Department of Veterans Affairs, Seattle, WA, USA.
Richard SloanDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Yi-An KoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Giulia Da PoianDepartment of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Erick A Perez-AldayDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Nancy MurrahDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Oleksiy M LevantsevychDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Lucy ShallenbergerDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Rami AbdulbakiDepartment of Pathology, Georgia Washington University Hospital, Washington, DC, USA.
Viola VaccarinoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine (Cardiology), School of Medicine, Emory University, Atlanta, GA, USA. Electronic address: viola.vaccarino@emory.edu.
Emory University · USColumbia University · USETH Zurich · CHGeorge Washington University Hospital · USUniversity of Pittsburgh · US

Funding

Mental Stress and Myocardial Ischemia after MI: Sex Differences, Mechanisms and PrognosisR01HL109413 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2012 to 2023
$6.9M
Mechanisms Linking Depression to Cardiovascular RiskR01HL068630 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2001 to 2010
$4.8M
PTSD and Ischemic Heart Disease Progression: A Longitudinal Twin StudyR01HL125246 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2015 to 2018
$3.4M
Sleep Disturbance as a Mechanism for Ischemic Heart Disease in PTSDR01HL136205 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2017 to 2020
$3.1M
Posttraumatic Stress Disorder and Cardiovascular DiseaseR01AG026255 · NIA · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2007
$2.8M
Mind-Body Interactions in Cardiovascular DiseaseK24HL077506 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2013
$1.5M
Cardiac Electrical Instability in Posttraumatic Stress Disorder: A Twin StudyR03HL146879 · NHLBI · EMORY UNIVERSITY · PI SHAH, AMIT JASVANT · 2019 to 2020
$156k
NHLBI NIH HHS K24 HL077506NHLBI NIH HHS R01 HL068630NHLBI NIH HHS R01 HL109413NHLBI NIH HHS R01 HL125246NHLBI NIH HHS R01 HL136205NHLBI NIH HHS R03 HL146879NIA NIH HHS R01 AG026255
6 · The paper itself

Abstract

introductionSleep disturbance is associated with autonomic dysregulation, but the temporal directionality of this relationship remains uncertain. The objective of this study was to evaluate the temporal relationships between objectively measured sleep disturbance and daytime or nighttime autonomic dysregulation in a co-twin control study.

methodsA total of 68 members (34 pairs) of the Vietnam Era Twin Registry were studied. Twins underwent 7-day in-home actigraphy to derive objective measures of sleep disturbance. Autonomic function indexed by heart rate variability (HRV) was obtained using 7-day ECG monitoring with a wearable patch. Multivariable vector autoregressive models with Granger causality tests were used to examine the temporal directionality of the association between daytime and nighttime HRV and sleep metrics, within twin pairs, using 7-day collected ECG data.

resultsTwins were all male, mostly white (96%), with mean (SD) age of 69 (2) years. Higher daytime HRV across multiple domains was bidirectionally associated with longer total sleep time and lower wake after sleep onset; these temporal dynamics were extended to a window of 48 h. In contrast, there was no association between nighttime HRV and sleep measures in subsequent nights, or between sleep measures from previous nights and subsequent nighttime HRV.

conclusionsDaytime, but not nighttime, autonomic function indexed by HRV has bidirectional associations with several sleep dimensions. Dysfunctions in autonomic regulation during wakefulness can lead to subsequent shorter sleep duration and worse sleep continuity, and vice versa, and their influence on each other may extend beyond 24 h.

Indexed as

Sleep Wake DisordersActigraphyAgedAutonomic Nervous SystemHeart RateHumansMalePolysomnographySleepActigraphyAutonomic nervous systemSleepTime series analysis

Identifiers

PMID35577169
PMCPMC10197091
OpenAlexW4280519190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.