Evidence map›Paper›PMID 35577119›Full record

ArticleThe Journal of pediatrics2022

Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children.

Melodie Aubart, Charles-Joris Roux, Chloé Durrleman, Clarisse Gins, Marie Hully, Manoelle Kossorotoff, Cyril Gitiaux, Raphaël Levy, Florence Moulin, Agathe Debray and 20 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Movement Disorders in MOGAD: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026
    Pooled it
  2. Pooled it
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  4. Review
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  6. Article
  7. Observational
  8. Article
  9. Article
  10. Susceptibility of SARS-CoV2 infection in children.European journal of pediatrics · 2023
    Review
  11. Article
  12. Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 13 institutions in 2 countries.

Melodie AubartPediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research U1163, University of Paris-Cité, Imagine Institute, Paris, France. Electronic address: melodie.aubart@aphp.fr.
Charles-Joris RouxPediatric Radiology Department, Necker-Enfats malades Hospital, APHP, University of Paris-Cité, Paris, France.
Chloé DurrlemanPediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Clarisse GinsPediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Marie HullyPediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Manoelle KossorotoffPediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Cyril GitiauxPediatric Neurophysiology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France; French Institute of Health and Medical Research U955-Team 10, Department of Neurosciences, Mondor Biomedical Research Institute, Paris-Est University, Créteil, France.
Raphaël LevyPediatric Radiology Department, Necker-Enfats malades Hospital, APHP, University of Paris-Cité, Paris, France.
Florence MoulinIntensive Care Unit, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Agathe DebrayPediatic Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Zahra BelhadjerPediatric Cardiology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Emilie GeorgetPediatic Department, Villeneuve Saint Georges Hospital, Villeneuve Saint Geroges, France.
Temi KomPediatic Department, Louis Pasteur Hospital, Le Coudray, France.
Philippe BlancPediatic Department, Poissy Intercommunal Hospital Center, Poissy, France.
Samer WehbiPediatic Department, Andre Mignot Hospital, Versailles, France.
Mustapha MazeghranePediatic Department, Andre Gregoire Hospital, Montreuil, France.
Jeremie TencerPediatic Department, Delafontaine Hospital, Saint Denis, France.
Vincent GajdosPediatic Department, Antoine Béclère Hospital, APHP, Paris-Saclay University, Clamart, France.
Sebastien RougetPediatic Department, Sud Francilien Hospital, Corbeil-Essone, France.
Loic De PontualPediatric Department, Jean Verdier Hospital, APHP, University of Paris-Cité, Bondy, France.
Romain BasmaciPediatric Department, Louis Mourier Hospital, APHP, University of Paris-Cité, Colombes, France.
Karima YacoubenPediatric Hematology Department, Robert Debre Hospital, APHP, University of Paris-Cité, Paris, France.
Francois AngoulvantPediatric Department, Robert Debre Hospital, APHP, University of Paris-Cité, Paris, France.
Marianne Leruez-VilleLaboratory of Virology, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Delphine SterlinImmunology Department, Pitié-Salpétrière Hospital, Sorbonne University, APHP, Paris, France.
Flore RozenbergLaboratory of Virology, Cochin Hospital, APHP, University of Paris-Cité, Paris, France.
Matthieu P RobertOphthalmology Department, Necker-Enfants Hospital, APHP, University of Paris-Cité, Paris, France.
Shen-Ying ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research U1163, University of Paris-Cité, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Nathalie BoddaertPediatric Radiology Department, Necker-Enfats malades Hospital, APHP, University of Paris-Cité, Paris, France.
Isabelle DesguerrePediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
Université Paris Cité · FRHôpital Necker-Enfants Malades · FRCentre de Réadaptation Cardiaque Les Grands Prés · FRCentre Hospitalier Intercommunal André Grégoire Montreuil · FRCentre Hospitalier Intercommunal de Poissy · FRCentre Hospitalier Saint-Denis · FRCentre Hospitalier Sud Francilien · FRDélégation Paris 5 · FRHôpital André Mignot · FRHôpital Pasteur · FRInserm · FRSorbonne Université · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe neurologic, radiologic and laboratory features in children with central nervous system (CNS) inflammatory disease complicating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. STUDY

designWe focused on CNS inflammatory diseases in children referred from 12 hospitals in the Paris area to Necker-Sick Children Reference Centre.

resultsWe identified 19 children who had a history of SARS-CoV-2 infection and manifest a variety of CNS inflammatory diseases: encephalopathy, cerebellar ataxia, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, or optic neuritis. All patients had a history of SARS-CoV-2 exposure, and all tested positive for circulating antibodies against SARS-CoV-2. At the onset of the neurologic disease, SARS-CoV-2 PCR results (nasopharyngeal swabs) were positive in 8 children. Cerebrospinal fluid was abnormal in 58% (11/19) and magnetic resonance imaging was abnormal in 74% (14/19). We identified an autoantibody co-trigger in 4 children (myelin-oligodendrocyte and aquaporin 4 antibodies), representing 21% of the cases. No autoantibody was found in the 6 children whose CNS inflammation was accompanied by a multisystem inflammatory syndrome in children. Overall, 89% of patients (17/19) received anti-inflammatory treatment, primarily high-pulse methylprednisolone. All patients had a complete long-term recovery and, to date, no patient with autoantibodies presented with a relapse.

conclusionsSARS2-CoV-2 represents a new trigger of postinfectious CNS inflammatory diseases in children.

Indexed as

COVID-19AutoantibodiesHumansMyelin-Oligodendrocyte GlycoproteinNeuroinflammatory DiseasesSARS-CoV-2Systemic Inflammatory Response SyndromeAutoantibodiesMyelin-Oligodendrocyte Glycoprotein

Identifiers

PMID35577119
PMCPMC9106400
OpenAlexW4280510589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.