Evidence map›Paper›PMID 35576730›Full record

ArticleEnvironment international2022

Quantile regression to examine the association of air pollution with subclinical atherosclerosis in an adolescent population.

Adjani A Peralta, Joel Schwartz, Diane R Gold, Judith M Vonk, Roel Vermeulen, Ulrike Gehring

Abstract read
In one paragraph

Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic review and meta-analysis on the health effects of long-term exposure to ultrafine particles.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. A Review of the Increasing Impact and Effects of Air Pollution Throughout Life and Before Birth.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Modelling Particulate Matter (PMAnalytical science advances · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adjani A PeraltaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, United States; Institute for Risk Assessment Sciences, Utrecht University, The Netherlands. Electronic address: aperalta@hsph.harvard.edu.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, United States. Electronic address: jschwrtz@hsph.harvard.edu.
Diane R GoldDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, United States. Electronic address: credrg@channing.harvard.edu.
Judith M VonkDepartment of Epidemiology and Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, The Netherlands. Electronic address: j.m.vonk@umcg.nl.
Roel VermeulenInstitute for Risk Assessment Sciences, Utrecht University, The Netherlands. Electronic address: r.c.h.vermeulen@uu.nl.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, The Netherlands. Electronic address: u.gehring@uu.nl.

Funding

CVD Epidemiology Training Program in Behavior, the Environment and Global HealthT32HL098048 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Goodarz Danaei, ERIC B RIMM · 2009 to 2026
$6.9M
NHLBI NIH HHS T32 HL098048
6 · The paper itself

Abstract

backgroundAir pollution has been associated with carotid intima-media thickness test (CIMT), a marker of subclinical atherosclerosis. To our knowledge, this is the first study to report an association between ambient air pollution and CIMT in a younger adolescent population.

objectiveTo investigate the associations beyond standard mean regression by using quantile regression to explore if associations occur at different percentiles of the CIMT distribution.

methodsWe measured CIMT cross-sectionally at the age of 16 years in 363 adolescents participating in the Dutch PIAMA birth cohort. We fit separate quantile regressions to examine whether the associations of annual averages of nitrogen dioxide (NO

resultsPM

conclusionsEarly childhood exposure to ambient air pollution was suggestively associated with the CIMT distribution during adolescence. Since CIMT increases with age, mitigation strategies to reduce traffic-related air pollution early in life could possibly delay atherosclerosis and subsequently CVD development later in life.

Indexed as

Air PollutantsAir PollutionAtherosclerosisAdolescentCarotid Intima-Media ThicknessChild, PreschoolEnvironmental ExposureHumansInfant, NewbornNitrogen DioxideParticulate MatterAir PollutantsNitrogen DioxideParticulate MatterAdolescentsAir pollutionAtherosclerosisCardiovascular diseaseEnvironmental EpidemiologyQuantile regression

Identifiers

PMID35576730
PMCPMC9890274

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.