Evidence map›Paper›PMID 35576622›Full record

ArticleACS applied bio materials2022

Fast-Curing Injectable Microporous Hydrogel for

Seth D Edwards, Shujie Hou, Jason M Brown, Ryann D Boudreau, Yuhan Lee, Young Jo Kim, Kyung Jae Jeong

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Injectable Methylcellulose/Hyaluronic Acid/Collagen Hydrogel Loaded With Adipose-Derived Stem Cells Alleviates Skin Photoaging via Inhibition of HIF-1α: An in Vitro and in Vivo Study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Granular Hydrogels for Harnessing the Immune Response.Advanced healthcare materials · 2024
    Review
  10. Article
  11. Article
  12. Hydrogels promote periodontal regeneration.Frontiers in bioengineering and biotechnology · 2024
    Review
  13. Dynamically crosslinked thermoresponsive granular hydrogels.Journal of biomedical materials research. Part A · 2023
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Seth D EdwardsDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire 03824, United States.
Shujie HouDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire 03824, United States.
Jason M BrownDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire 03824, United States.
Ryann D BoudreauDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire 03824, United States.
Yuhan LeeEngineering in Medicine, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Young Jo KimDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire 03824, United States.
Kyung Jae JeongDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire 03824, United States.ORCID 0000-0002-8749-9830
University of New Hampshire · USBrigham and Women's Hospital · US

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI W Kelley THOMAS · 2017 to 2026
$22.8M
MMP-deactivating injectable hydrogel for chronic woundsR21EB032134 · NIBIB · UNIVERSITY OF NEW HAMPSHIRE · PI JEONG, KYUNG JAE, KIM, YOUNG JO · 2021 to 2023
$599k
Contact lens to remove zinc ions for corneal meltingR21EY027953 · NEI · UNIVERSITY OF NEW HAMPSHIRE · PI JEONG, KYUNG JAE, LEE, JUNG-JAE · 2018 to 2019
$433k
NEI NIH HHS R21 EY027953NIBIB NIH HHS R21 EB032134NIGMS NIH HHS P20 GM113131
6 · The paper itself

Abstract

Injectable hydrogels have previously demonstrated potential as a temporary scaffold for tissue regeneration or as a delivery vehicle for cells, growth factors, or drugs. However, most injectable hydrogel systems lack a microporous structure, preventing host cell migration into the hydrogel interior and limiting spreading and proliferation of encapsulated cells. Herein, an injectable microporous hydrogel assembled from gelatin/gelatin methacryloyl (GelMA) composite microgels is described. Microgels are produced by a water-in-oil emulsion using a gelatin/GelMA aqueous mixture. These microgels show improved thermal stability compared to GelMA-only microgels and benefit from combined photopolymerization using UV irradiation (365 nm) in the presence of a photoinitiator (PI) and enzymatic reaction by microbial transglutaminase (mTG), which together enable fast curing and tissue adhesion of the hydrogel. The dual-crosslinking approach also allows for the reduction of PI concentration and minimizes cytotoxicity during photopolymerization. When applied for

Indexed as

Mesenchymal Stem CellsMicrogelsCell EncapsulationGelatinHumansHydrogelsMethacrylatesTissue EngineeringGelatingelatin methacryloylHydrogelsMethacrylatesMicrogelsanti-inflammatorygelatininjectable hydrogelsmesenchymal stem cell deliverymicroporoustissue adhesion

Identifiers

PMID35576622
PMCPMC9290187
OpenAlexW4280553131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.