Evidence map›Paper›PMID 35576468›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

Jérémy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat and 188 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 2 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 2 syntheses or guidelines pooled it, 183 citations in OpenAlex.

  1. Pooled it
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  6. High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  7. Observational
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

198 authors at 20 institutions in 28 countries.

Jérémy ManryLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0002-5926-8437
Adrian GervaisLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Tom Le VoyerLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Jérémie RosainLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0002-2822-161X
Quentin PhilippotLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Eleftherios MichailidisLaboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065.ORCID 0000-0002-9907-4346
Hans-Heinrich HoffmannLaboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065.
Shohei EtoDepartment of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Marina Garcia-PratPediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Lucy BizienLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Alba Parra-MartínezPediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Rui YangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.ORCID 0000-0003-4427-2158
Liis HaljasmägiInstitute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia.
Mélanie MigaudLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Karita SärekannuInstitute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia.
Julia MaslovskajaInstitute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia.
Nicolas de ProstService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France.
Yacine Tandjaoui-LambiotteHypoxia and Lung, INSERM U1272, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, 93022 Bobigny, France.
Charles-Edouard LuytSorbonne Université, Hôpital Pitié Salpêtrière, Médecine Intensive Réanimation, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France.
Blanca Amador-BorreroInternal Medicine Department, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, 75010 Paris, France.
Alexandre GaudetINSERM U1019-CNRS UMR9017, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, University of Lille, 59000 Lille, France.
Julien PoissyINSERM U1019-CNRS UMR9017, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, University of Lille, 59000 Lille, France.
Pascal MorelEtablissement Français du Sang, 93218 La Plaine Saint-Denis, France.
Pascale RichardEtablissement Français du Sang, 93218 La Plaine Saint-Denis, France.
Fabrice CognasseSanté Ingéniérie Biologie St-Etienne (SAINBIOSE), INSERM U1059, University of Lyon, Université Jean Monnet Saint-Etienne, 42000 Saint-Étienne, France.
Jesús TroyaDepartment of Internal Medicine, Infanta Leonor University Hospital, 28031 Madrid, Spain.ORCID 0000-0001-7323-114X
Sophie Trouillet-AssantHospices Civils de Lyon, 69002 Lyon, France.
Alexandre BelotHospices Civils de Lyon, 69002 Lyon, France.
Kahina SakerHospices Civils de Lyon, 69002 Lyon, France.
Pierre GarçonIntensive Care Unit, Grand Hôpital de l'Est Francilien Site de Marne-La-Vallée, 77600 Jossigny, France.
Jacques G RivièrePediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Jean-Christophe LagierMicrobes, Evolution, Phylogénie et Infection (MEPHI), Institut Hospitalo-Universitaire Méditerranée Infection, Institut de Recherche pour le Développement, Assistance Publique Hôpitaux de Marseille, Aix-Marseille Université, 13005 Marseille, France.
Stéphanie GentileService d'Evaluation Médicale, Hôpitaux Universitaires de Marseille Assistance Publique Hôpitaux de Marseille, 13005 Marseille, France.
Lindsey B RosenLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Elana ShawLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Tomohiro MorioDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Junko TanakaDepartment of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
David DalmauHospital Universitari MútuaTerrassa, Universitat de Barcelona, 08193 Barcelona, Spain.
Pierre-Louis TharauxParis Cardiovascular Research Center (PARCC), INSERM, Université de Paris, 75015 Paris, France.ORCID 0000-0002-6062-5905
Damien SeneInternal Medicine Department, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, 75010 Paris, France.
Alain StepanianService d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université de Paris, 75010 Paris, France.
Bruno MégarbaneRéanimation Médicale et Toxicologique, Hôpital Lariboisière Assistance Publique-Hôpitaux de Paris, Université de Paris, INSERM, UMRS-1144, 75010 Paris, France.
Vasiliki TriantafylliaLaboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Arnaud FekkarLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
James R HeathInstitute for Systems Biology, Seattle, WA 98109.
José Luis FrancoPrimary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UdeA, 050010 Medellín, Colombia.
Juan-Manuel AnayaCenter for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 110111 Bogotá, Colombia.
Jordi Solé-ViolánIntensive Care Medicine, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, 35010 Las Palmas de Gran Canaria, Spain.
Luisa ImbertiCHemato-oncology Research Laboratory of Associazione italiana contro le leucemie-linfomi e mieloma, Diagnostic Departement, Azienda Socio Sanitaria Territoriale, Spedali Civili di Brescia, 25123 Brescia, Italy.
Andrea BiondiPediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN), University of Milano Bicocca, Fondazione Monza Brianza Bambino Mamma (MBBM), Ospedale San Gerardo, 20900 Monza, Italy.
Paolo BonfantiDepartment of Infectious Diseases, San Gerardo Hospital, University of Milano Bicocca, 20900 Monza, Italy.ORCID 0000-0001-7289-8823
Riccardo CastagnoliLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Yu ZhangLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Andrew L SnowDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.ORCID 0000-0002-8728-6691
Steven M HollandLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Catherine M BiggsDepartment of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC V6H 0B3, Canada.
Marcela Moncada-VélezSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.
Andrés Augusto AriasSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.
Lazaro LorenzoLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Soraya BoucheritLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Dany AnglicheauDepartment of Nephrology and Transplantation, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, 75743 Paris, France.
Anna M PlanasInstitute for Biomedical Research, Spanish National Research Council, 08036 Barcelona, Spain.ORCID 0000-0002-6147-1880
Filomeen HaerynckDepartment of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, 9000 Ghent, Belgium.
Sotirija DuvlisFaculty of Medical Sciences, University "Goce Delchev," Štip 2000, Republic of North Macedonia.
Tayfun OzcelikDepartment of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey.
Sevgi KelesMeram Faculty of Medicine, Necmettin Erbakan University, 42080 Konya, Turkey.
Ahmed A BousfihaClinical Immunology Unit, Department of Pediatric Infectious Disease, Centre Hospitalier-Universitaire Ibn Roucshd, 20360 Casablanca, Morocco.
Jalila El BakkouriClinical Immunology Unit, Department of Pediatric Infectious Disease, Centre Hospitalier-Universitaire Ibn Roucshd, 20360 Casablanca, Morocco.
Carolina Ramirez-SantanaCenter for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 111211 Bogotá, Colombia.
Stéphane PaulDepartment of Immunology, CIC1408, Groupe sur l'Immunité des Muqueuses et des Agents Pathogènes (GIMAP) Centre International de Recherche en Infectiologie, INSERM U1111, University Hospital of Saint-Étienne, 42000 Saint-Étienne, France.ORCID 0000-0002-8830-4273
Qiang Pan-HammarströmDepartment of Biosciences and Nutrition, Karolinska Institutet, 171 77 Stockholm, Sweden.
Lennart HammarströmDepartment of Biosciences and Nutrition, Karolinska Institutet, 171 77 Stockholm, Sweden.
Annabelle DupontUniversity of Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France.
Alina KurolapThe Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel.
Christine N MetzFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030.
Alessandro AiutiVita-Salute San Raffaele University, and Clinical Genomics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy.
Giorgio CasariVita-Salute San Raffaele University, and Clinical Genomics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy.
Vito LampasonaDiabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy.
Fabio CiceriHematology and Bone Marrow Transplantation Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele University Vita-Salute San Raffaele, 20132 Milano, Italy.
Lucila A BarreirosDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-060 São Paulo, Brazil.
Elena Dominguez-GarridoFundación Rioja Salud, Centro de Investigación Biomédica de La Rioja, 26006 Logroño, Spain.
Mateus VidigalUniversity of São Paulo, 05508-060 São Paulo, Brazil.
Mayana ZatzUniversity of São Paulo, 05508-060 São Paulo, Brazil.
Diederik van de BeekDepartment of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
Sabina SahanicDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Ivan TancevskiDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Yurii StepanovskyyShupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine.
Oksana BoyarchukDepartment of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, 46022 Ternopil, Ukraine.
Yoko NukuiDepartment of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo 113-8655, Japan.
Miyuki TsumuraDepartment of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Loreto VidaurIntensive Care Medicine, Donostia University Hospital, Biodonostia Institute of Donostia, 20014 San Sebastián, Spain.
Stuart G TangyeGarvan Institute of Medical Research, Sydney, NWS 2010, Australia.
Sonia BurrelSorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Service de Virologie, 75013 Paris, France.
Darragh DuffyTranslational Immunology Unit, Institut Pasteur, Université Paris Cité, 75015 Paris, France.ORCID 0000-0002-8875-2308
Lluis Quintana-MurciHuman Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015 Paris, France.
Adam KlocperkDepartment of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, 150 06 Prague, Czech Republic.
Nelli Y KannDepartment of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 117997.
Anna ShcherbinaDepartment of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 117997.
Yu-Lung LauDepartment of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong 999077, China.
Daniel LeungDepartment of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong 999077, China.
Matthieu CoulongeatDivision of Geriatric Medicine, Tours University Medical Center, 37044 Tours, France.
Julien MarletINSERM U1259, Morphogenèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours, 37044 Tours, France.ORCID 0000-0002-8645-8703
Rutger KoningDepartment of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
Luis Felipe ReyesDepartment of Microbiology, Universidad de La Sabana, 250001 Chía, Colombia.
Angélique Chauvineau-GrenierService de Biologie Médicale, Centre Hospitalier Intercommunal Robert Ballanger, 93600 Aulnay-sous-Bois, France.
Fabienne VenetLaboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.ORCID 0000-0003-0462-4235
Guillaume MonneretLaboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.
Michel C NussenzweigLaboratory of Molecular Immunology, Rockefeller University, New York, NY 10065.
Romain ArrestierService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France.
Idris BoudhabhayDepartment of Nephrology and Transplantation, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, 75743 Paris, France.
Hagit Baris-FeldmanThe Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel.
David HaginSackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel.
Joost WautersMedical Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium.
Isabelle MeytsLaboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Adam H DyerDepartment of Age-Related Healthcare, Tallaght University Hospital, Dublin D24 NR0A, Ireland.ORCID 0000-0003-1356-510X
Sean P KennellyDepartment of Age-Related Healthcare, Tallaght University Hospital, Dublin D24 NR0A, Ireland.
Nollaig M BourkeDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland.
Rabih HalwaniSharjah Institute for Medical Research, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates.
Fatemeh Saheb Sharif-AskariSharjah Institute for Medical Research, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates.
Karim DorghamSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, 75013 Paris, France.
Jérôme SalletteCerba HealthCare, 92130 Issy-les-Moulineaux, France.
Souad Mehlal SedkaouiCerba HealthCare, 92130 Issy-les-Moulineaux, France.
Suzan AlKhaterDepartment of Pediatrics, King Fahad Hospital of the University, Al Khobar 34445, Saudi Arabia.
Raúl Rigo-BonninDepartment of Clinical Laboratory, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Francisco MorandeiraDepartment of Immunology, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Lucie RousselDepartment of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC H4A 3J1, Canada.
Donald C VinhDepartment of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC H4A 3J1, Canada.
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, 8000 Aarhus, Denmark.
Antonio Condino-NetoDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-060 São Paulo, Brazil.ORCID 0000-0002-1069-3117
Carolina PrandoFaculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, 80250-200 Curitiba, Brazil.
Anastasiia BondarenkoShupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine.
András N SpaanSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.
Laurent GilardinService de Médecine Interne, Hôpital Universitaire Jean-Verdier, Assistance Publique-Hôpitaux de Paris, 93140 Bondy, France.
Jacques FellaySchool of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.ORCID 0000-0002-8240-939X
Stanislas LyonnetImagine Institute, Université de Paris, INSERM, UMR 1163, 75015 Paris, France.
Kaya BilguvarYale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06511.
Richard P LiftonInstitute for Biomedical Research, Spanish National Research Council, 08036 Barcelona, Spain.
Shrikant ManeDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06520.
HGID Lab
COVID Clinicians
COVID-STORM Clinicians
NIAID Immune Response to COVID Group
NH-COVAIR Study Group
Danish CHGE
Danish Blood Donor Study
St. James's Hospital, SARS CoV2 Interest Group
French COVID Cohort Study Group
Imagine COVID-Group
Milieu Intérieur Consortium
CoV-Contact Cohort
Amsterdam UMC Covid-19 Biobank Investigators
COVID Human Genetic Effort
CP-COVID-19 Group
CONSTANCES cohort
3C-Dijon Study
Cerba Health-Care
Etablissement Français du Sang Study group
Mark S AndersonInstitut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain.
Bertrand BoissonLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0001-5240-3555
Vivien BéziatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0002-4020-824X
Shen-Ying ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Evangelos AndreakosLaboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Olivier HermineImagine Institute, University of Paris, 75015 Paris, France.
Aurora PujolNeurometabolic Diseases Laboratory, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Pärt PetersonInstitute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia.
Trine H MogensenDepartment of Infectious Diseases, Aarhus University Hospital, 8000 Aarhus, Denmark.
Lee RowenInstitute for Systems Biology, Seattle, WA 98109.
James MondADMA Biologics Inc., Ramsey, NJ 07446.
Stéphanie DebetteUniversity of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France.
Xavier de LamballerieInstitut Hospitalo-Universitaire Méditerranée Infection, Unité des Virus Émergents, Aix-Marseille University, Institut pour la Recherche et le Développment (IRD) 190, INSERM 1207, 13005 Marseille, France.
Charles BurdetEpidémiologie clinique du Centre d'Investigation Clinique (CIC-EP), INSERM CIC 1425, Hôpital Bichat, 75018 Paris, France.
Lila BouadmaUniversité de Paris, Infection Antimicrobials Modelling Evolution (IAME), UMR 1137, INSERM, 75870 Paris, France.
Marie ZinsCohorte Constances Groupe Hospitalier Universitaire centre, Assistance Publique-Hôpitaux de Paris, Université de Paris, 94800 Villejuif, France.
Pere Soler-PalacinPediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Roger ColobranImmunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Guy GorochovSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, 75013 Paris, France.ORCID 0000-0003-2097-9677
Xavier SolanichDepartment of Internal Medicine, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0002-2572-2187
Sophie SusenUniversity of Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France.
Javier Martinez-PicadoIrsiCaixa AIDS Research Institute, 08916 Badalona, Spain.ORCID 0000-0002-4916-2129
Didier RaoultMicrobes, Evolution, Phylogénie et Infection (MEPHI), Institut Hospitalo-Universitaire Méditerranée Infection, Institut de Recherche pour le Développement, Assistance Publique Hôpitaux de Marseille, Aix-Marseille Université, 13005 Marseille, France.
Marc VasseService de Biologie Clinique and UMR-S 1176, Hôpital Foch, 92150 Suresnes, France.
Peter K GregersenFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030.
Lorenzo PiemontiDiabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy.
Carlos Rodríguez-GallegoDepartment of Clinical Sciences, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Helen C SuLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.
Kai KisandInstitute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia.
Satoshi OkadaDepartment of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0003-2603-0323
Emmanuelle JouanguyLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Charles M RiceLaboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065.ORCID 0000-0003-3087-8079
Pierre TiberghienEtablissement Français du Sang, 93218 La Plaine Saint-Denis, France.
Qian ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0002-9040-3289
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0002-7782-4169
Laurent AbelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.
Aurélie CobatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0001-7209-6257
Inserm · FRUniversitat Autònoma de Barcelona · ESUniversité Claude Bernard Lyon 1 · FRCentre National de la Recherche Scientifique · FRNational Institute of Allergy and Infectious Diseases · USUniversidade de São Paulo · BRUniversité Paris Cité · FRHiroshima University · JPKarolinska Institutet · SEKU Leuven · BERockefeller University · USVita-Salute San Raffaele University · ITAix-Marseille Université · FRAmsterdam Neuroscience · NLBellvitge University Hospital · ESTrinity College Dublin · IEUniversity of Hong Kong · HKUniversity of Tartu · EEAcademy of Athens · GRCentre Hospitalier Universitaire Ibn Rochd · MA

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
TRANSFORMING TRANSLATIONAL SCIENCE AND EDUCATION TO BENEFIT HUMAN HEALTHUL1RR024143 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2006 to 2011
$49.1M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Understanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI RAVETCH, JEFFREY VICTOR · 2014 to 2023
$26.0M
Yale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8M
Host factors contributing to susceptibility to COVID-19 diseaseZIAAI001265 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2020 to 2025
$9.5M
Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7M
Type I interferon-stimulated genes and the antiviral immune responseR01AI091707 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2011 to 2020
$5.5M
NHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9M
Inborn errors of immunity in patients with life-threatening COVID-19R01AI163029 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, ZHANG, QIAN · 2021 to 2025
$3.7M
Characterization of host immune responses to SARS-CoV-2ZIAAI001270 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2020 to 2025
$1.2M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysiS10OD018521 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2015 to 2015
$890k
Intramural NIH HHS ZIA AI001265Intramural NIH HHS ZIA AI001270NCATS NIH HHS UL1 TR001866NCI NIH HHS 75N91019D00024NCRR NIH HHS UL1 RR024143NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG006504NIAID NIH HHS R01 AI088364NIAID NIH HHS R01 AI091707NIAID NIH HHS R01 AI163029NIAID NIH HHS U19 AI111825NIH HHS S10 OD018521
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.

Indexed as

Antibodies, NeutralizingAutoantibodiesAutoimmunityCOVID-19Interferon Type ISARS-CoV-2AdultAgedAged, 80 and overAge FactorsFemaleHumansMaleMiddle AgedRiskAntibodies, NeutralizingAutoantibodiesInterferon Type IautoantibodiesCOVID-19infection fatality raterelative risktype I IFNs

Identifiers

PMID35576468
PMCPMC9173764
OpenAlexW4280525750

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