Evidence map›Paper›PMID 35576458›Full record

ArticleMicrobial biotechnology2022

Washed preparation of faecal microbiota changes the transplantation related safety, quantitative method and delivery.

Gaochen Lu, Weihong Wang, Pan Li, Quan Wen, Bota Cui, Faming Zhang

4 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06256614 recruitingnot on this mapstarted 2024, after this paper: background citation

Washed Microbiota Transplantation for Type 1 Diabetes Mellitus: a Real World Research

TypeobservationalSponsorThe Second Hospital of Nanjing Medical UniversityRan2024 to 2029Enrolled50ConditionsType 1 DiabetesArmsWMT
NCT06487299 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

Iron Administration Via Colonic Transendoscopic Enteral Tubing Combined With Washed Microbiota Transplantation for Iron Deficiency:A Double-blind Randomized Controlled Trial

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2024 to 2026Enrolled60ConditionsIron Deficiency Anemia in ChildbirthArmsFerrous Lactate, Iron sucrose, 0.9% NaCl solution
NCT06708676 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Washed Microbiota Transplantation for Postoperative Complications in Solid Organ Transplantation

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2024 to 2030Enrolled50ConditionsSolid Organ Transplant ComplicationsArmsWashed Microbiota Transplantation
NCT06730451 recruitingnot on this map

Washed Microbiota Transplantation for Postoperative Complications in Solid Organ Transplantation

TypeobservationalSponsorThe Second Hospital of Nanjing Medical UniversityRan2018 to 2028Enrolled50ConditionsSolid Organ Transplant ComplicationsArmsWashed Microbiota Transplantation
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. [Fecal Microbiota Transplantation: A Promising Avenue for Lung Cancer Therapy].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gaochen LuMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Weihong WangMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Pan LiMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Quan WenMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Bota CuiMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Faming ZhangMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.ORCID 0000-0003-4157-1144
Second Affiliated Hospital of Nanjing Medical University · CNNational Clinical Research Center for Digestive Diseases · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The safety, quantitative method and delivery of faecal microbiota transplantation (FMT) vary a lot from different countries in practice. Recently, the improved methodology of FMT based on the automatic filtration, washing process and the related delivery was named as washed microbiota transplantation (WMT). First, this study aimed to describe the methodology development of FMT from manual to washing preparation from 2012 to 2021 in China Microbiota Transplantation System (CMTS), a centralized stool bank for providing a national non-profit service. The secondary aim is to describe donor screenings, the correlation between faecal weight and treatment doses, incidence of adverse events and delivery decision. The retrospective analysis on the prospectively recorded data was performed. Results showed that the success rate of donor screening was 3.1% (32/1036). The incidence rate of fever decreased significantly from 19.4% (6/31) in manual FMT to 2.7% (24/902) in WMT in patients with ulcerative colitis (UC), which made UC a considerable disease model to reflect the quality control of faecal microbiota preparation. We defined one treatment unit as 10 cm

Indexed as

Colitis, UlcerativeMicrobiotaFecal Microbiota TransplantationFecesHumansRetrospective StudiesTreatment Outcome

Identifiers

PMID35576458
PMCPMC9437882
OpenAlexW4280625435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.