Evidence map›Paper›PMID 35576449›Full record

ReviewHarvard review of psychiatry

An Integrated Neuroimaging Approach to Inform Transcranial Electrical Stimulation Targeting in Visual Hallucinations.

Nicolas Raymond, Robert M G Reinhart, Matcheri Keshavan, Paulo Lizano

Open access · greenAbstract readReview
In one paragraph

Review in Harvard review of psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicolas RaymondFrom the Department of Psychiatry (Mr. Raymond and Drs. Keshavan and Lizano) and Division of Translational Neuroscience (Mr. Raymond and Dr. Lizano), Beth Israel Deaconess Medical Center, Boston, MA; Department of Psychological and Brain Sciences, Boston University, Boston, MA (Dr. Reinhart); Harvard Medical School (Drs. Keshavan and Lizano).
Robert M G Reinhart
Matcheri Keshavan
Paulo Lizano
Boston Medical Center · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Retinal Layer, Microvascular and Electroretinographic Determinants of Early Course SchizophreniaK23MH122701 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LIZANO, PAULO L · 2021 to 2024
$768k
NCATS NIH HHS UL1 TR002541NIMH NIH HHS K23 MH122701
6 · The paper itself

Abstract

abstractFor decades, noninvasive brain stimulation (NIBS), such as transcranial electrical stimulation (tES), has been used to directly modulate human brain mechanisms of visual perception, setting the groundwork for the development of novel circuit-based therapies. While the field of NIBS has grown considerably over recent years, few studies have used these technologies to treat visual hallucinations (VH). Here, we review the NIBS-VH literature and find mixed results due to shortcomings that may potentially be addressed with a unique multimodal neuroimaging-NIBS approach. We highlight methodological advances in NIBS research that have provided researchers with more precise anatomical measurements that may improve our ability to influence brain activity. Specifically, we propose a methodology that combines neuroimaging advances, clinical neuroscience developments such as the identification of brain regions causally involved in VH, and personalized NIBS approaches that improve anatomical targeting. This methodology may enable us to reconcile existing discrepancies in tES-VH research and pave the way for more effective, VH-specific protocols for treating a number of neuropsychiatric disorders with VH as a core symptom.

Indexed as

Transcranial Direct Current StimulationBrainHallucinationsHumansNeuroimagingTranscranial Magnetic Stimulation

Identifiers

PMID35576449
PMCPMC9179829
OpenAlexW4280562280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.