Evidence map›Paper›PMID 35576050›Full record

ArticleMolecular biology reports2022

Evaluation of serum haptoglobin levels and Hp1-Hp2 polymorphism in the haptoglobin gene in patients with atrial fibrillation.

Luana Bernardes Xavier Costa, Gabriela Lopes Martins, Rita Carolina Figueiredo Duarte, Pâmella Lemos Rocha, Estêvão Lanna Figueiredo, Francisco Rezende Silveira, Maria das Graças Carvalho, Helton José Reis, Karina Braga Gomes, Cláudia Natália Ferreira

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Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Luana Bernardes Xavier CostaFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Gabriela Lopes MartinsDepartamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Rita Carolina Figueiredo DuarteFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Pâmella Lemos RochaFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Estêvão Lanna FigueiredoHospital Lifecenter, Belo Horizonte, MG, Brazil.
Francisco Rezende SilveiraHospital Semper, Belo Horizonte, MG, Brazil.
Maria das Graças CarvalhoFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Helton José ReisDepartamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Karina Braga GomesFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Cláudia Natália FerreiraFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. ferreiracn@gmail.com.ORCID http://orcid.org/0000-0003-4545-6821
Universidade Federal de Minas Gerais · BRLifecenter Hospital · BR

Funding

FAPEMIG 2071001094/2020FAPEMIG APQ-00812-12FAPEMIG APQ 02196-16
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is an arrhythmia that involves structural and electrophysiological abnormalities. Many of the AF-related clinical conditions are associated with an increase in inflammatory and oxidative factors. Haptoglobin (Hp) is an acute phase protein whose biological role is to promote clearance of free hemoglobin (Hb). In addition, for being considered an inflammatory marker, Hp represents a protective mechanism against the oxidative effects of Hb. The Hp1-Hp2 polymorphism at Hp locus can lead to three phenotypes related to structural and functional differences in the protein. The objective of this study were to evaluate Hp levels and Hp1-Hp2 polymorphism at Hp locus in patients with AF compared to a control group. METHODS AND

resultsThis study included 65 patients with AF and 54 individuals without the arrhythmia. Biochemical parameters were determined using Vitros system, plasma levels of Hp were measured in serum samples by using ELISA method and polymorphisms were verified by PCR technique. Plasma Hp levels, as well as allelic and genotypic frequency, were not associated with AF. The levels of Hp also did not differ among the genotypes according to the applied models.

conclusionsThe results suggest that Hp levels and Hp1-Hp2 polymorphism are not associated to AF.

Indexed as

Atrial FibrillationHaptoglobinsGenotypeHemoglobinsHumansPolymorphism, GeneticHaptoglobinsHemoglobinsHP protein, humanAtrial fibrillationGenotypingHaptoglobinPolymorphism

Identifiers

PMID35576050
OpenAlexW4280563030

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.