Evidence map›Paper›PMID 35576020›Full record

ArticleArchives of microbiology2022

Whole-genome sequence analysis of Clostridium chauvoei isolated from clinical case of black quarter (BQ) from India.

Awadhesh Prajapati, Revanaiah Yogisharadhya, Nihar Nalini Mohanty, Suresh Kumar Mendem, Azharuddin Nizamuddin, Mohammed Mudassar Chanda, Sathish Bhadravati Shivachandra

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Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Awadhesh PrajapatiICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Karnataka, 560064, Bengaluru, India.
Revanaiah YogisharadhyaICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Karnataka, 560064, Bengaluru, India.
Nihar Nalini MohantyCCS-National Institute of Animal Health (NIAH), Baghpat, Uttar Pradesh, 250609, India.
Suresh Kumar MendemICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Karnataka, 560064, Bengaluru, India.
Azharuddin NizamuddinDepartment of Animal Husbandry and Veterinary Services, State Semen Collection Centre, Hessarghatta, Bengaluru, Karnataka, 560089, India.
Mohammed Mudassar ChandaICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Karnataka, 560064, Bengaluru, India.
Sathish Bhadravati ShivachandraICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Karnataka, 560064, Bengaluru, India. sb.shivachandra@icar.gov.in.ORCID http://orcid.org/0000-0002-3575-5564

Funding

indian council of agricultural research IXX12176
6 · The paper itself

Abstract

Black quarter (BQ) is an infectious disease affecting cattle and small ruminants worldwide caused by Gram-positive anaerobic bacterium Clostridium chauvoei. In this study, a draft genome sequence of C. chauvoei NIVEDIBQ1 strain isolated from clinical case of black quarter was analyzed. Sequence analysis indicated that genome had 2653 predicted coding DNA sequences, harbored numerous genes, mobile genetic elements for pathogenesis, and virulence factors. Computational analysis revealed that strain contained 30 virulence-associated genes. An intact genomic region highly similar to the Clostridium phage was present in the genome. Presence of CRISPR systems and the transposon components likely contribute to the genome plasticity. Strain encode diverse spectrum of degradative carbohydrate-active enzymes (CAZymes). Comparative SNP analysis revealed that the genomes of the C. chauvoei strains analyzed were highly conserved. Phylogenetic analysis of strains and available genome (n = 21) based on whole-genome multi-locus sequence typing (wgMLST) and core orthologous genes showed the clustering of strains into two different clusters suggesting geographical links.

Indexed as

Clostridium chauvoeiAnimalsBase CompositionCattleGenome, BacterialMultilocus Sequence TypingPhylogenyRNA, Ribosomal, 16SSequence Analysis, DNARNA, Ribosomal, 16SBlack quarterClostridium chauvoeiGenome analysisIndia

Identifiers

PMID35576020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.