Evidence map›Paper›PMID 35575807›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

Reduced hip bone mineral density is associated with high levels of calciprotein particles in patients with Fabry disease.

S Bruell, K M Nicholls, T D Hewitson, A S Talbot, S G Holt, E R Smith, I Ruderman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The formation and function of calciprotein particles.Pflugers Archiv : European journal of physiology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

S BruellDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.ORCID https://orcid.org/0000-0002-8419-6711
K M NichollsDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
T D HewitsonDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.ORCID https://orcid.org/0000-0002-1994-2423
A S TalbotDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
S G HoltDepartment of Medicine (RMH), University of Melbourne, Parkville, Australia.
E R Smith *Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia. edward.smith@mh.org.au.
I Ruderman *Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
The Royal Melbourne Hospital · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calciprotein particles (CPP) are nanoscale mineralo-protein aggregates that help stabilize excess mineral in the circulation. We examined the relationship between CPP and bone mineral density in Fabry disease patients. We found an inverse correlation with total hip and femoral neck density, but none with lumbar spine. PURPOSE: Calciprotein particles (CPP) are colloidal mineral-protein complexes made up primarily of the circulating glycoprotein fetuin-A, calcium, and phosphate. They form in extracellular fluid and facilitate the stabilization, transport, and clearance of excess minerals from the circulation. While most are monomers, they also exist in larger primary (CPP-I) and secondary (CPP-II) form, both of which are reported to be raised in pathological states. This study sought to investigate CPP levels in the serum of patients with Fabry disease, an X-linked systemic lysosomal storage disorder that is associated with generalized inflammation and low bone mineral density (BMD).

methodsWe compared serum CPP-I and CPP-II levels in 59 patients with Fabry disease (37 female) with levels in an age-matched healthy adult cohort (n=28) and evaluated their association with BMD and biochemical data obtained from routine clinical review.

resultsCPP-I and CPP-II levels were higher in male Fabry disease patients than female sufferers as well as their corresponding sex- and age-matched controls. CPP-II levels were inversely correlated with BMD at the total hip and femoral neck, but not the lumbar spine. Regression analyses revealed that these associations were independent of common determinants of BMD, but at the femoral neck, a significant association was only found in female patients.

conclusionLow hip BMD was associated with high CPP-II in patients with Fabry disease, but further work is needed to investigate the relevance of sex-related differences and to establish whether CPP measurement may aid assessment of bone disease in this setting.

Indexed as

alpha-2-HS-GlycoproteinFabry DiseaseAdultBone DensityCalciumFemaleHumansMaleMineralsPhosphatesProtein Aggregatesalpha-2-HS-GlycoproteinCalciumMineralsPhosphatesProtein AggregatesBone mineral densityCalciprotein particlesDXAFabry diseaseFetuin-ALysosomal storage disorders

Identifiers

PMID35575807
PMCPMC9499881
OpenAlexW4280617552

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.