Evidence map›Paper›PMID 35575720›Full record

ArticleOrganic letters2022

Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis.

Alejandro Prieto-Castañeda, Fernando García-Garrido, Carolina Díaz-Norambuena, Blanca Escriche-Navarro, Alba García-Fernández, Jorge Bañuelos, Esther Rebollar, Inmaculada García-Moreno, Ramón Martínez-Máñez, Santiago de la Moya and 2 more

Abstract read
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alejandro Prieto-CastañedaDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Fernando García-GarridoDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Carolina Díaz-NorambuenaDepartamento de Química-Física, Universidad del País Vasco-EHU, Apartado 644, 48080 Bilbao, Spain.
Blanca Escriche-NavarroUnidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universidad Politécnica de Valencia, Centro de Investigación Príncipe Felipe, Carrer d'Eduardo Primo Yúfera 3, 46012 Valencia, Spain.
Alba García-FernándezUnidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universidad Politécnica de Valencia, Centro de Investigación Príncipe Felipe, Carrer d'Eduardo Primo Yúfera 3, 46012 Valencia, Spain.
Jorge BañuelosDepartamento de Química-Física, Universidad del País Vasco-EHU, Apartado 644, 48080 Bilbao, Spain.ORCID 0000-0002-8444-4383
Esther RebollarDepartamento de Sistemas de Baja Dimensionalidad, Superficies y Materia Condensada, Instituto de Química-Física "Rocasolano", CSIC, Serrano 119, 28006 Madrid, Spain.
Inmaculada García-MorenoDepartamento de Sistemas de Baja Dimensionalidad, Superficies y Materia Condensada, Instituto de Química-Física "Rocasolano", CSIC, Serrano 119, 28006 Madrid, Spain.
Ramón Martínez-MáñezUnidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universidad Politécnica de Valencia, Centro de Investigación Príncipe Felipe, Carrer d'Eduardo Primo Yúfera 3, 46012 Valencia, Spain.ORCID 0000-0001-5873-9674
Santiago de la MoyaDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.ORCID 0000-0002-7406-909X
Antonia R AgarrabeitiaDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
María J OrtizDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.ORCID 0000-0002-0394-4045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.

Indexed as

PhotochemotherapyBoron CompoundsPhotosensitizing AgentsPolymers4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsPhotosensitizing AgentsPolymers

Identifiers

PMID35575720
PMCPMC9150176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.