Evidence map›Paper›PMID 35575694›Full record

ArticleACS applied bio materials2022

Amine Functionalized Trimetallic Nitride Endohedral Fullerenes: A Class of Nanoparticle to Tackle Low Back/Leg Pain.

Li Xiao, Rong Huang, Nurul Sulimai, Ricky Yao, Brock Manley, Peng Xu, Robin Felder, Li Jin, Harry C Dorn, Xudong Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Li XiaoDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, United States.ORCID 0000-0003-1403-7472
Rong HuangDepartment of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
Nurul SulimaiDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, United States.
Ricky YaoDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, United States.
Brock ManleyDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, United States.
Peng XuDepartment of Pathology, University of Virginia, Charlottesville, Virginia 22908, United States.
Robin FelderDepartment of Pathology, University of Virginia, Charlottesville, Virginia 22908, United States.
Li JinDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, United States.
Harry C DornDepartment of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-3150-5314
Xudong LiDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, United States.ORCID 0000-0002-2688-740X
University of Virginia · USBiomedical Research Institute · USVirginia Tech · US

Funding

Deciphering Macrophage Phenotype and Function in Disc Herniation and associated Back/leg PainR01AR078888 · NIAMS · UNIVERSITY OF VIRGINIA · PI XUDONG J. LI · 2022 to 2026
$1.8M
Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat BR01AR064792 · NIAMS · UNIVERSITY OF VIRGINIA · PI LI, XUDONG J. · 2013 to 2018
$1.3M
Disc-on-a-chip: microfluidic nutrition and biomechanical loading integrated mouse disc culture systemR21AR072334 · NIAMS · UNIVERSITY OF VIRGINIA · PI LI, XUDONG J. · 2018 to 2019
$391k
An ex vivo system to model the inflammatory microenvironment of human disc herniationR21AR078547 · NIAMS · UNIVERSITY OF VIRGINIA · PI LI, XUDONG J., POMPANO, REBECCA R · 2021 to 2021
$388k
Treatment of disc degeneration by nano-fullerenesR21AR057512 · NIAMS · UNIVERSITY OF VIRGINIA · PI LI, XUDONG J. · 2011 to 2012
$381k
NIAMS NIH HHS R01 AR064792NIAMS NIH HHS R01 AR078888NIAMS NIH HHS R21 AR057512NIAMS NIH HHS R21 AR072334NIAMS NIH HHS R21 AR078547
6 · The paper itself

Abstract

Low back pain is the most common health problem with a prevalence of over 80% worldwide and an estimated annual cost of $100 billion in the United States. Intervertebral disc degeneration accounts for a major cause of low back pain. However, there is still a lack of safe and effective treatment to tackle this devastating condition. In this study, we synthesized four functionalized trimetallic nitride endohedral metallofullerenes (carboxyl-f-Sc

Indexed as

FullerenesIntervertebral Disc DegenerationLow Back PainNanoparticlesAminesAnimalsMiceTumor Necrosis Factor-alphaAminesFullerenesTumor Necrosis Factor-alphafullereneinflammationintervertebral disc degenerationlow back painnanomedicinenanoparticlestrimetallic nitride endohedral metallofullerenes

Identifiers

PMID35575694
PMCPMC9719410
OpenAlexW4280534142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.