Evidence map›Paper›PMID 35575581›Full record

ArticleJournal of bacteriology2022

The WalRK Two-Component System Is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile.

Ute Müh, Craig D Ellermeier, David S Weiss

Open access · hybridAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. CenIR, an essential BlaIR-family regulatory system inbioRxiv : the preprint server for biology · 2026
    Article
  3. A multifunctional probiotic co-delivery platform for the treatment of Clostridium difficile infection.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  4. Analysis of essential genes inJournal of bacteriology · 2025
    Article
  5. Analysis of Essential Genes inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Microbiology spectrum · 2024
    Article
  9. Identification of a family of peptidoglycan transpeptidases reveals thatProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Identification of DraRS inJournal of bacteriology · 2023
    Article
  13. Article
  14. Butyrate enhancesJournal of bacteriology · 2023
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ute MühDepartment of Microbiology and Immunology, University of Iowagrid.214572.7, Iowa City, Iowa, USA.
Craig D EllermeierDepartment of Microbiology and Immunology, University of Iowagrid.214572.7, Iowa City, Iowa, USA.ORCID 0000-0002-8953-5081
David S WeissDepartment of Microbiology and Immunology, University of Iowagrid.214572.7, Iowa City, Iowa, USA.ORCID 0000-0003-2217-0070
University of Iowa · US

Funding

Identification of daptomycin resistance mechanisms in Clostridioides difficileR01AI087834 · NIAID · UNIVERSITY OF IOWA · PI ELLERMEIER, CRAIG D · 2011 to 2025
$5.6M
Cell Envelope Biogenesis in Clostridioides difficileR01AI155492 · NIAID · UNIVERSITY OF IOWA · PI ELLERMEIER, CRAIG D, WEISS, DAVID S · 2021 to 2025
$2.6M
NIAID NIH HHS R01 AI087834NIAID NIH HHS R01 AI155492
6 · The paper itself

Abstract

The WalR-WalK two-component regulatory system (TCS) is found in all

Indexed as

Clostridioides difficileAnti-Bacterial AgentsBacillus subtilisBacterial ProteinsClostridioidesGene Expression Regulation, BacterialAnti-Bacterial AgentsBacterial Proteinscell enveloperegulation of gene expressionsignal transduction

Identifiers

PMID35575581
PMCPMC9210968
OpenAlexW4280560630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.