Evidence map›Paper›PMID 35575547›Full record

ArticlemBio2022

A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP.

Negar Shahsavari, Boyuan Wang, Yu Imai, Miho Mori, Sangkeun Son, Libang Liang, Nils Böhringer, Sylvie Manuse, Michael F Gates, Madeleine Morrissette and 5 more

Abstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. A chlorinated diketopiperazine antibiotic targetsAntimicrobial agents and chemotherapy · 2025
    Article
  5. Article
  6. ExploringMolecules (Basel, Switzerland) · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Negar Shahsavari *Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Boyuan Wang *Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yu ImaiAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Miho MoriAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Sangkeun SonAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Libang LiangAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Nils BöhringerInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany.
Sylvie ManuseAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Michael F GatesAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Madeleine MorrissetteAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Rachel CorsettiAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Josh L EspinozaJ. Craig Venture Institute, La Jolla, California, USA.
Chris L DupontJ. Craig Venture Institute, La Jolla, California, USA.
Michael T LaubDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-8288-7607
Kim LewisAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.ORCID 0000-0002-1621-7664

Funding

Uncultured bacteria for the discovery of novel antimicrobialsP01AI118687 · NIAID · NORTHEASTERN UNIVERSITY · PI LEWIS, KIM · 2016 to 2020
$8.9M
In-depth characterization of the metabolic effect of the bacterial alamorne ppGppK99GM135536 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WANG, BOYUAN · 2020 to 2021
$200k
NIAID NIH HHS P01 AI118687NIGMS NIH HHS K99 GM135536
6 · The paper itself

Abstract

With the overmining of actinomycetes for compounds acting against Gram-negative pathogens, recent efforts to discover novel antibiotics have been focused on other groups of bacteria. Teixobactin, the first antibiotic without detectable resistance that binds lipid II, comes from an uncultured

Indexed as

Biological ProductsEscherichia coli ProteinsNematodaPhotorhabdusProdrugsXenorhabdusAnimalsAnti-Bacterial AgentsBacterial Outer Membrane ProteinsDeoxyguanosineEscherichia coliGram-Negative BacteriaGuanosineGuanosine TriphosphateOperonAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBamA protein, E coliBiological ProductsDeoxyguanosineEscherichia coli ProteinsGuanosineGuanosine TriphosphateProdrugsantibiotic resistancenatural productnucleoside analog

Identifiers

PMID35575547
PMCPMC9239236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.