Evidence map›Paper›PMID 35575535›Full record

ArticleMicrobiology spectrum2022

Azole Resistance-Associated Regulatory Motifs within the Promoter of

Alexander Kühbacher, Mandy Peiffer, Peter Hortschansky, Petra Merschak, Michael J Bromley, Hubertus Haas, Axel A Brakhage, Fabio Gsaller

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Pathogenesis and Triazole Resistance inInfection and drug resistance · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Loss of a conserved C-terminal region of thebioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Alexander KühbacherInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Mandy PeifferInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Peter HortschanskyDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Petra MerschakInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Michael J BromleyManchester Fungal Infection Group, Division of Infection, Immunity, and Respiratory Medicine, The University of Manchestergrid.5379.8, Manchester, United Kingdom.
Hubertus HaasInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Axel A BrakhageDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.ORCID 0000-0002-8814-4193
Fabio GsallerInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATLeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversity of Manchester · GB

Funding

Austrian Science Fund FWF P 31093
6 · The paper itself

Abstract

Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase in rates of resistance and the poor therapeutic outcomes for patients infected with a resistant isolate constitute a serious global health threat. Azole resistance is frequently associated with specific tandem repeat duplications of a promoter element upstream of

Indexed as

AspergillosisAspergillus fumigatusAntifungal AgentsAzolesCytochrome P-450 Enzyme SystemDrug Resistance, FungalFungal ProteinsHumansIronMicrobial Sensitivity TestsAntifungal AgentsAzolesCytochrome P-450 Enzyme SystemFungal ProteinsIronAspergillus fumigatusazole resistancecyp51Airon regulationregulatory elementstranscription factors

Identifiers

PMID35575535
PMCPMC9241776
OpenAlexW4280553552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.