Evidence map›Paper›PMID 35575476›Full record

ArticleeLife2022

Transcription elongation is finely tuned by dozens of regulatory factors.

Mary Couvillion, Kevin M Harlen, Kate C Lachance, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Co-transcriptional gene regulation in eukaryotes and prokaryotes.Nature reviews. Molecular cell biology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Context-dependent function of the transcriptional regulator Rap1 in gene silencing and activation inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. New roles for elongation factors in RNA polymerase II ubiquitylation and degradation.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mary Couvillion *Blavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.
Kevin M Harlen *Blavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.
Kate C Lachance *Blavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.
Kristine L TrottaBlavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.ORCID 0000-0002-8166-7696
Erin SmithBlavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.
Christian BrionBlavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.
Brendan M SmalecBlavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.
L Stirling ChurchmanBlavatnik Institute, Department of Genetics, Harvard Medical School, Boston, United States.ORCID 0000-0003-3888-2574

Funding

Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8M
Mechanisms of Transcriptional Control Revealed by Nascent Transcript SequencingR01HG007173 · NHGRI · HARVARD MEDICAL SCHOOL · PI Lee Stirling Churchman · 2013 to 2026
$6.7M
PFinder: A computational tool to identify genomic regions affected by perturbationF31HG010570 · NHGRI · HARVARD MEDICAL SCHOOL · PI LACHANCE, KATHERINE COYNE · 2019 to 2020
$57k
NHGRI NIH HHS F31 HG010570NHGRI NIH HHS R01 HG007173NHGRI NIH HHS T32 HG002295
6 · The paper itself

Abstract

Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NET-seq) in 41 strains of

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsBase SequenceRNA Polymerase IITranscriptional Elongation FactorsTranscription, GeneticRNA Polymerase IISaccharomyces cerevisiae ProteinsTranscriptional Elongation Factorsantisense transcriptionchromosomesgene expressiongeneticsgenomicsPol II pausingS. cerevisiaetranscription elongation

Identifiers

PMID35575476
PMCPMC9154744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.