Evidence map›Paper›PMID 35575473›Full record

ArticleeLife2022

DNA-PK promotes DNA end resection at DNA double strand breaks in G

Faith C Fowler, Bo-Ruei Chen, Nicholas Zolnerowich, Wei Wu, Raphael Pavani, Jacob Paiano, Chelsea Peart, Zulong Chen, André Nussenzweig, Barry P Sleckman and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Identification of the main barriers to Ku accumulation in chromatin.bioRxiv : the preprint server for biology · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Lost in the bloom: DNA-PKcs in green plants.Frontiers in plant science · 2023
    Article
  17. Article
  18. Dynamic features of human mitochondrial DNA maintenance and transcription.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Faith C FowlerWeill Cornell Medicine Pharmacology Graduate Program, New York, United States.ORCID 0000-0002-7180-8141
Bo-Ruei ChenDepartment of Medicine, Division of Hematology and Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0001-6404-2099
Nicholas ZolnerowichLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Wei WuLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Raphael PavaniLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Jacob PaianoLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Chelsea PeartWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, United States.
Zulong ChenWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, United States.
André NussenzweigLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Barry P SleckmanDepartment of Medicine, Division of Hematology and Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0001-8295-4462
Jessica K TylerWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, United States.ORCID 0000-0001-9765-1659
Cancer Institute (WIA) · INCornell University · USUniversity of Alabama at Birmingham · US

Funding

DNA RepairZIABC010283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0M
Relationship between DNA damage detection and signalingZIABC010959 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0M
THE V(D)J RECOMBINATION REACTION AND ITS IMPACT ON LYMPHOCYTE DEVELOPMENTR01AI047829 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SLECKMAN, BARRY P · 2000 to 2021
$7.0M
ATM FUNCTION DURING V(D)J RECOMBINATIONR01AI074953 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SLECKMAN, BARRY P · 2009 to 2023
$5.9M
Chromatin's Role in Repair of Radiation-induced Damage.R01CA095641 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2002 to 2023
$5.2M
Novel pathways that regulate DNA double-strand break repair events in mammalian cellsR35GM139816 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2021 to 2025
$2.1M
The Role of Chromatin in the Repair of Radiation-Induced DamageF31CA239442 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI FOWLER, FAITH · 2019 to 2021
$131k
NCI NIH HHS F31 CA239442NCI NIH HHS R01 CA095641NIAID NIH HHS R01 AI047829NIAID NIH HHS R01 AI074953NIGMS NIH HHS R35 GM139816
6 · The paper itself

Abstract

DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G

Indexed as

DNA Breaks, Double-StrandedF-Box ProteinsAnimalsDNADNA-Activated Protein KinaseDNA End-Joining RepairDNA RepairG1 PhaseHumansMiceDNADNA-Activated Protein KinaseF-Box ProteinsFBXL12 protein, mousechromosomesDNA double strand breaksDNA end resectionDNA-PKgene expressiongenome stabilitymammalian cellsmouseRPA

Identifiers

PMID35575473
PMCPMC9122494
OpenAlexW4280491403

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.