ArticleJournal of the National Cancer Institute2022
Impact of HIV on Anal Squamous Cell Carcinoma Rates in the United States, 2001-2015.
Article in Journal of the National Cancer Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Design and initial findings of a natural history study of anal HPV and associated lesions among young adult women in Costa Rica.International journal of cancer · 2025Trial
- Therapy for squamous-cell carcinoma of the anus in HIV-positive patients.ESMO gastrointestinal oncology · 2026Review
- Article
- HIV-Associated Lymphomas: Updates from Pathogenesis to Treatment Strategies.Current HIV research · 2026Review
- Advanced Cutaneous Squamous Cell Carcinoma: Biology, Immunotherapy, and Evolving Prognostic Factors.Biomedicines · 2025Review
- Article
- Review
- Racial and ethnic differences in HPV-related cancer incidence in the United States, 2001-2020.Journal of the National Cancer Institute · 2025Article
- Disentangling the Complex Relationships Between Autoimmune Diseases and Cancer Through Polygenic Risk Scores: Evidence from a Large Prospective Study.Research square · 2025Article
- Racial disparities in cancer risk among MSM with HIV in the United States.AIDS (London, England) · 2025Article
- National Analysis of More Than 48,000 Veterans With HIV Demonstrates CD4/CD8 Ratio as a Risk Marker for Anal Intraepithelial Lesions and Anal Cancer.Diseases of the colon and rectum · 2025Article
- PAP-HPV Co-Testing in Anal Cancer Screening: An Italian Experience.Journal of clinical medicine · 2025Article
- Demographic, clinical, and social characteristics of anal cancer among patients stratified by age (<50 and ≥50 years) in Alabama between 2012 and 2018.Cancer epidemiology · 2024Article
- Future patterns in burden and incidence of squamous cell carcinoma of the anus in the United States, 2001-2035.Journal of the National Cancer Institute · 2024Article
- Recent and projected incidence trends and risk of anal cancer among people with HIV in North America.Journal of the National Cancer Institute · 2024Article
- Prevalence of anal cytology screening among persons with HIV and lack of access to high-resolution anoscopy at HIV care facilities.Journal of the National Cancer Institute · 2024Article
- Article
- Autoimmune disease and the risk of anal cancer in the US population aged 66 years and over.Journal of the National Cancer Institute · 2024Article
- Severe anal intraepithelial neoplasia trends and subsequent invasive anal cancer in the United States.Journal of the National Cancer Institute · 2024Article
- Survival by sex and HIV status in patients with anal cancer in the USA between 2001 and 2019: a retrospective cohort study.The lancet. HIV · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundIncidence of anal squamous cell carcinoma (SCC) has increased in the United States. People living with HIV (PLWH) have an elevated risk of anal SCC, and changes in the number of anal SCCs among PLWH may have influenced general population trends.
methodsData were obtained from a linkage of HIV and cancer registries in 12 US regions. The proportion of anal SCCs occurring among PLWH was estimated by sex, age group, and race and ethnicity. To assess the impact of anal SCCs among PLWH on general population trends, annual percent changes (APCs) in incidence rates including and excluding anal SCCs among PLWH were estimated.
resultsBetween 2001 and 2015, 14.5% of 16 110 anal SCC diagnoses occurred in PLWH. In 2013-2015, 35% of anal SCCs among men occurred in PLWH, but only 2% among women. The proportion of anal SCCs among PLWH was highest among 20- to 49-year-olds and Black and Hispanic individuals. General population anal SCC trends among men were strongly influenced by anal SCCs among PLWH: rates increased 4.6%/y (95% confidence interval [CI] = 1.4% to 8.0%) from 2001 to 2009 followed by a statistically non-significant decline (APC = -2.7%/y, 95% CI = -7.1% to 2.0%) from 2009 to 2015, but without anal SCCs among PLWH, rates were stable (APC = 0.7%/y, 95% CI = -0.8% to 2.3%). Anal SCC rates among women increased 3.8%/y (95% CI = 3.2% to 4.4%) during 2001-2012 and then declined statistically non-significantly (APC = -3.8%/y, 95% CI = -6.9% to -0.6%), and anal SCCs among PLWH had little impact on these trends.
conclusionsDuring 2001-2015, anal SCCs among PLWH contributed strongly to changes in incidence trends in the general US population among men, but not women.
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