ArticleACS macro letters2022
Plasmonic Detection of SARS-CoV-2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods.
Article in ACS macro letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Coordination-cage-templated multivalent glycan arrays: effects of mixed-glycan composition and chain length on lectin binding.Chemical science · 2026Article
- Carbohydrate-based biosensors for enhanced pathogen detection.Analytical and bioanalytical chemistry · 2026Review
- Overview on the Sensing Materials and Methods Based on Reversible Addition-Fragmentation Chain-Transfer Polymerization.Biosensors · 2025Review
- Glycopolymer-Functionalized Gold Nanoparticles for the Detection of Western Diamondback Rattlesnake (Biomacromolecules · 2025Article
- Polymer-Grafted Gold Colloids and Supracolloids: From Mechanisms of Formation to Dynamic Soft Matter.Macromolecular rapid communications · 2025Review
- A Nanoplasmonic Assay for Point-of-Care Detection of Mannose-Binding Lectin in Human Serum.ACS applied materials & interfaces · 2024Article
- Recent Advances in Polymers Bearing Activated Esters for the Synthesis of Glycopolymers by Postpolymerization Modification.Polymers · 2024Review
- Sialic acids in infection and their potential use in detection and protection against pathogens.RSC chemical biology · 2024Review
- Programmable Monodisperse Glyco-Multivalency Using Self-Assembled Coordination Cages as Scaffolds.ACS applied materials & interfaces · 2023Article
- Achieving broad availability of SARS-CoV-2 detections via smartphone-based analysis.Trends in analytical chemistry : TRAC · 2023Review
- Plasmonic Biosensors with Nanostructure for Healthcare Monitoring and Diseases Diagnosis.Sensors (Basel, Switzerland) · 2022Review
- Development and Application of an SPR Nanobiosensor Based on AuNPs for the Detection of SARS-CoV-2 on Food Surfaces.Biosensors · 2022Article
- Article
- Cysteine-Encapsulated Liposome for Investigating Biomolecular Interactions at Lipid Membranes.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has highlighted the need for innovative biosensing, diagnostic, and surveillance platforms. Here we report that glycosylated, polymer-stabilized, gold nanorods can bind the SARS-CoV-2 spike protein and show correlation to the presence of SARS-CoV-2 in primary COVID-19 clinical samples. Telechelic polymers were prepared by reversible addition-fragmentation chain-transfer polymerization, enabling the capture of 2,3-sialyllactose and immobilization onto gold nanorods. Control experiments with a panel of lectins and a galactosamine-terminated polymer confirmed the selective binding. The glycosylated rods were shown to give dose-dependent responses against recombinant truncated SARS-CoV-2 spike protein, and the responses were further correlated using primary patient swab samples. The essentiality of the anisotropic particles for reducing the background interference is demonstrated. This highlights the utility of polymer tethering of glycans for plasmonic biosensors of infection.
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