Evidence map›Paper›PMID 35575287›Full record

SynthesisThe American surgeon2023

Beta-Blocker Therapy in Patients With Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.

Israel Zagales, Sruthi Selvakumar, Micah Ngatuvai, Dino Fanfan, Lucy Kornblith, Radleigh G Santos, Joseph Ibrahim, Adel Elkbuli

Expression of concernAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The American surgeon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Israel ZagalesUniversidad Iberoamericana (UNIBE) Escuela de Medicina, Santo Domingo, Dominican Republic.
Sruthi SelvakumarDr. Kiran.C. Patel College of Allopathic Medicine, NSU NOVA Southeastern University, Fort Lauderdale, FL, USA.
Micah NgatuvaiDr. Kiran.C. Patel College of Allopathic Medicine, NSU NOVA Southeastern University, Fort Lauderdale, FL, USA.
Dino FanfanHerbert Wertheim College of Medicine,Florida International University, Miami, FL, USA.
Lucy KornblithDivision of Trauma and Surgical Critical Care, Department of Surgery, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA.
Radleigh G SantosDepartment of Mathematics, NSU NOVA Southeastern University, Fort Lauderdale, FL, USA.
Joseph IbrahimDivision of Trauma and Surgical Critical Care, Department of Surgery, Orlando Regional Medical Center, Orlando, FL, USA.
Adel ElkbuliDivision of Trauma and Surgical Critical Care, Department of Surgery, Orlando Regional Medical Center, Orlando, FL, USA.
Nova Southeastern University · USOrlando Regional Medical Center · USFlorida International University · USSan Francisco General Hospital · USUniversidad Iberoamericana · DO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTraumatic brain injury (TBI), a leading cause of morbidity and mortality among trauma patients worldwide, poses the risk of secondary neurological insult due to significant catecholamine surge. We aim to investigate the effectiveness and outcomes of beta-blocker administration in patients with severe TBI.

methodsA search through PubMed, EMBASE, JAMA network, and Google Scholar databases was conducted for relevant peer-reviewed original studies published before February 15, 2022. A standard random-effects model was used, as justified by a high Cohen's Q test.

resultsTwelve studies met inclusion criteria and were included in the meta-analysis. Severe TBI patients who were administered beta-blockers had a significantly reduced incidence of in-hospital mortality compared to the non-beta-blocker group (14.5% vs 19.2%). However, the beta-blocker group was reported to have a significantly greater number of ventilator days (5.58 vs 2.60 days). Similarly, intensive care unit (9.00 vs 6.84 days) and hospital (17.30 vs 11.02 days) lengths of stay (LOS) were increased in the beta-blocker group compared to those who were not administered beta-blocker therapy, but only the difference in hospital-LOS was significant.

conclusionsBeta-blockers have significantly decreased in-hospital mortality in patients with severe TBI despite being associated with an increase in ventilator days and hospital-LOS. The administration of beta-blocker therapy in the management of severe TBI may be warranted and should be discussed in future guidelines.

Indexed as

Brain InjuriesBrain Injuries, TraumaticAdrenergic beta-AntagonistsHumansIntensive Care UnitsLength of StayAdrenergic beta-Antagonistsbeta-blockerspractice management guidelinestrauma outcomestraumatic brain injuries

Identifiers

PMID35575287
OpenAlexW4280588552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.