SynthesisJournal of the American Heart Association2022
Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Hand Dominance Influences Motor Recovery Trajectories Following Stroke: A Longitudinal Study.Sensors (Basel, Switzerland) · 2026Article
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- A multi-cohort study of the hippocampal radiomics model and its associated biological changes in Alzheimer's Disease.Translational psychiatry · 2024Article
- National and international collaborations to advance research into vascular contributions to cognitive decline.Cerebral circulation - cognition and behavior · 2024Article
- Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke.Neurology · 2023Observational
- SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry.Science advances · 2023Article
- Functional MRI in Radiology-A Personal Review.Healthcare (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors.
Artemis Zavaliangos-PetropuluMark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA.ORCID 0000-0003-1953-8663
Bethany LoChan Division of Occupational Science and Occupational Therapy University of Southern California Los Angeles CA.ORCID 0000-0001-7626-9020
Miranda R DonnellyChan Division of Occupational Science and Occupational Therapy University of Southern California Los Angeles CA.
Nicolas SchweighoferBiokinesiology and Physical Therapy University of Southern California Los Angeles CA.ORCID 0000-0003-3362-6088
Keith LohsePhysical Therapy and Neurology Washington University School of Medicine in Saint Louis MO.
Neda JahanshadMark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA.
Giuseppe BarisanoMark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA.ORCID 0000-0001-5598-1369
Nerisa BanajLaboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy.ORCID 0000-0002-6317-8549
Michael R BorichDivision of Physical Therapy Department of Rehabilitation Medicine Emory University School of Medicine Atlanta GA.ORCID 0000-0001-9897-9867
Lara A BoydDepartment of Physical Therapy University of British Columbia Vancouver Canada.
Cathrin M BuetefischDepartment of Neurology School of Medicine Emory University Atlanta GA.
Winston D ByblowDepartment of Exercise Sciences, and Centre for Brain Research University of Auckland New Zealand.
Jessica M CassidyDepartment of Allied Health Sciences University of North Carolina at Chapel Hill NC.ORCID 0000-0003-3469-0399
Charalambos C CharalambousDepartment of Basic and Clinical Sciences University of Nicosia Medical School Nicosia Cyprus.ORCID 0000-0002-1547-1839
Adriana B ConfortoHospital das Clínicas São Paulo University São Paulo Brazil.
Julie A DiCarloCenter for Neurotechnology and Neurorecovery (CNTR) Massachusetts General Hospital Boston MA.ORCID 0000-0002-9141-4035
Adrienne N DulaDepartment of Neurology Dell Medical School University of Texas at Austin TX.ORCID 0000-0002-4809-6115
Natalia Egorova-BrumleyMelbourne School of Psychological Sciences University of Melbourne Parkville Victoria Australia.
Mark R EthertonDepartment of Neurology J. Philip Kistler Stroke Research Center Massachusetts General Hospital Boston MA.ORCID 0000-0002-4739-2449
Wuwei FengDepartment of Neurology Duke University School of Medicine Durham NC.ORCID 0000-0001-6230-4905
Kelene A FerchoBasic Biomedical Sciences University of South Dakota Vermillion SD.
Fatemeh GeranmayehBrain Sciences Imperial College London London United Kingdom.ORCID 0000-0003-1112-786X
Colleen A HanlonWake Forest School of Medicine Winston Salem NC.
Kathryn S HaywardDepartments of Physiotherapy and Medicine, University of Melbourne Heidelberg Victoria Australia.ORCID 0000-0001-5240-3264
Brenton HordacreInnovation, Implementation and Clinical Translation (IIMPACT) in Health Allied Health and Human Performance University of South Australia Adelaide South Australia Australia.
Steven A KautzRalph H Johnson Veterans Affairs Medical Center Charleston SC.
Mohamed Salah KhlifThe Florey Institute of Neuroscience and Mental Health Heidelberg Victoria Australia.
Hosung KimMark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA.
Amy KuceyeskiDepartment of Radiology Weill Cornell Medicine New York NY.ORCID 0000-0002-5050-8342
David J LinCenter for Neurotechnology and Neurorecovery (CNTR) Massachusetts General Hospital Boston MA.
Jingchun LiuDepartment of Radiology Tianjin Medical University General Hospital Tianjin China.
Martin LotzeFunctional Imaging Institute for Diagnostic Radiology and Neuroradiology University Medicine Greifswald Germany.
Bradley J MacIntoshHurvitz Brain Sciences Program Sunnybrook Research Institute Toronto Canada.ORCID 0000-0001-7300-2355
John L MargetisChan Division of Occupational Science and Occupational Therapy University of Southern California Los Angeles CA.
Feroze B MohamedDepartment of Radiology Jefferson Integrated MR Center Thomas Jefferson University Philadelphia PA.
Fabrizio PirasLaboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy.ORCID 0000-0003-3566-5494
Ander Ramos-MurguialdayInstitute of Medical Psychology and Behavioral Neurobiology University of Tübingen Germany.ORCID 0000-0002-1549-4029
Kate P RevillDepartment of Psychology Emory University Atlanta GA.ORCID 0000-0001-9497-7987
Pamela S RobertsChan Division of Occupational Science and Occupational Therapy University of Southern California Los Angeles CA.
Andrew D RobertsonDepartment of Kinesiology and Health Sciences University of Waterloo Ontario Canada.ORCID 0000-0002-9095-9877
Heidi M SchambraDepartments of Neurology & Rehabilitation Medicine NYU Langone New York NY.ORCID 0000-0002-1886-2288
Na Jin SeoRalph H Johnson Veterans Affairs Medical Center Charleston SC.ORCID 0000-0001-6446-5905
Mark S ShiroishiMark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA.ORCID 0000-0002-1422-0288
Cathy M StinearDepartment of Medicine University of Auckland New Zealand.ORCID 0000-0002-9404-1959
Surjo R SoekadarClinical Neurotechnology Laboratory Department of Psychiatry and Neurosciences (CCM) Charité - Universitätsmedizin Berlin Berlin Germany.
Gianfranco SpallettaLaboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy.
Myriam TagaNYU Langone Department of Neurology New York NY.
Wai Kwong TangDepartment of Psychiatry The Chinese University of Hong Kong China.ORCID 0000-0002-3661-8684
Gregory T ThielmanDepartment of Physical Therapy and Neuroscience University of the Sciences Philadelphia PA.
Daniela VecchioLaboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy.ORCID 0000-0001-8428-7376
Nick S WardUniversity College London Queen Square Institute of Neurology London United Kingdom.
Lars T WestlyeDepartment of Psychology University of Oslo Norway.ORCID 0000-0001-8644-956X
Emilio WerdenThe Florey Institute of Neuroscience and Mental Health Heidelberg Victoria Australia.
Carolee WinsteinBiokinesiology and Physical Therapy University of Southern California Los Angeles CA.ORCID 0000-0001-9789-4626
George F WittenbergDepartment of Neurology University of Pittsburgh PA.ORCID 0000-0001-5603-1197
Steven L WolfDivision of Physical Therapy Department of Rehabilitation Medicine Emory University School of Medicine Atlanta GA.ORCID 0000-0002-9446-8995
Kristin A WongDepartment of Physical Medicine & Rehabilitation Dell Medical School University of Texas at Austin TX.
Chunshui YuDepartment of Radiology Tianjin Medical University General Hospital Tianjin China.ORCID 0000-0001-5648-5199
Amy BrodtmannThe Florey Institute of Neuroscience and Mental Health Heidelberg Victoria Australia.ORCID 0000-0001-9466-2862
Steven C CramerDepartment of Neurology University of California Los Angeles David Geffen School of Medicine Los Angeles CA.
Paul M ThompsonMark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA.
Sook-Lei LiewMark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA.ORCID 0000-0001-5935-4215
Funding
Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5MTreating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5MCorticoreticulospinal Tract Reorganization After StrokeR01NS110696 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHAMBRA, HEIDI · 2019 to 2023
$3.2MSupplement to Effects of global brain health on sensorimotor recovery after strokeR01NS115845 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIEW, SOOK-LEI · 2020 to 2024
$3.2MRole of distinctive cortical motor maps for hand muscles for recovery post strokeR01HD094731 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SEO, NA JIN · 2020 to 2024
$3.1MCustomized cortical stimulation therapy in the rehabilitation of stroke patientsR01NS090677 · NINDS · EMORY UNIVERSITY · PI BUETEFISCH, CATHRIN M · 2015 to 2018
$3.0MReorganizing motor cortex in stroke patient through Hebbian-type stimulationR21HD067906 · NICHD · EMORY UNIVERSITY · PI BUETEFISCH, CATHRIN M · 2011 to 2012
$464kCombined brain and peripheral nerve stimulation to enhance beneficial effects ofR01NS076348 · NINDS · FUNDACAO FACULDADE DE MEDICINA · PI CONFORTO, ADRIANA B · 2012 to 2015
$441kRR&D Research Career Scientist Award ApplicationIK6RX003075 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI KAUTZ, STEVEN A. · 2020 to 2025
–Medical Research Council MR/T001402/1Medical Research Council MR/X502959/1NICHD NIH HHS R01 HD094731NIGMS NIH HHS P20 GM109040NIGMS NIH HHS U54 GM104941NINDS NIH HHS R01 NS076348NINDS NIH HHS R01 NS110696Wellcome Trust
Abstract
Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results Cross-sectional T1-weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta-Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA-UE (Fugl-Meyer Assessment of Upper Extremity). Robust mixed-effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected,
Indexed as
StrokeStroke RehabilitationCross-Sectional StudiesFemaleHippocampusHumansMaleQuality of LifeRecovery of FunctionUpper ExtremityhippocampusMRIsensorimotor impairmentstroke
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