ArticleJournal of the American Heart Association2022
Nitrite Generating and Depleting Capacity of the Oral Microbiome and Cardiometabolic Risk: Results from ORIGINS.
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Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- A pilot randomized controlled trial of the effects of dietary nitrate supplementation on dynamic cerebral autoregulation in older adults with metabolic syndrome.Physiological reports · 2026Trial
- Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular-Kidney-Metabolic Syndrome.International journal of molecular sciences · 2026Review
- The Oral Microbiome-Nitrate-Nitrite-Nitric Oxide Axis and Cardiovascular Health: A Narrative Review.Journal of clinical medicine · 2026Review
- Population-scale characterization of the oral microbiome and associations with metabolic health.Nature communications · 2026Article
- Higher salivary nitrite is associated with improved glycemic control and insulin sensitivity in patients with type 2 diabetes.Nutrition & metabolism · 2026Article
- Article
- Dietary Nitrate Intake and 16S rRNA-Inferred Nitrite-Generating Capacity of the Subgingival Microbiome May Influence Glucose Metabolism: Results From the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS).Journal of clinical periodontology · 2026Article
- Dual probiotic intervention with Lactiplantibacillus plantarum Kmiate-6 and Pediococcus acidilactici Kmiate-15 improves periodontal health and oral microbiota balance in dogs.Animal microbiome · 2026Article
- Oral microbiome diversity and mortality in metabolic syndrome: a cohort study.Journal of oral microbiology · 2026Article
- Comparative genomic analysis of hydrogen peroxide and nitric oxide metabolic pathways in Limosilactobacillus fermentum.Scientific reports · 2025Article
- The Effect of Chlorhexidine Mouthwashes on the Microbiota Associated with Peri-Implantitis Lesions: A Pilot Study.Antibiotics (Basel, Switzerland) · 2025Article
- Proton Pump Inhibitor Use and Incident Hypertension in Menopausal Women.Journal of the American Heart Association · 2025Observational
- The blood pressure lowering effect of beetroot juice is impaired in periodontitis and recovered after periodontal treatment.NPJ biofilms and microbiomes · 2025Article
- Nitrate reduction by salivary bacteria, glucose metabolism, and lifestyle.Journal of oral microbiology · 2025Article
- Quantifying periodontitis-associated oral dysbiosis in tongue and saliva microbiomes-An integrated data analysis.Journal of periodontology · 2025Article
- Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
- Diagnostic potential of salivary microbiota in persistent pulmonary nodules: identifying biomarkers and functional pathways using 16S rRNA sequencing and machine learning.Journal of translational medicine · 2024Article
- The Connection Between the Oral Microbiota and the Kynurenine Pathway: Insights into Oral and Certain Systemic Disorders.Current issues in molecular biology · 2024Review
- A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation.Signal transduction and targeted therapy · 2024Review
- Clinical attachment loss is cross-sectionally associated with elevated glucose among adults without diabetes.Journal of clinical periodontology · 2024Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 3 countries.
Charlene E GohFaculty of Dentistry National University of Singapore Singapore.ORCID 0000-0002-2208-5397
Bruno BohnDivision of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN.ORCID 0000-0001-8961-6968
Clarisse MarotzDepartment of Pediatrics University of California San Diego La Jolla CA.ORCID 0000-0002-1520-8854
Rebecca MolinskyDivision of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN.ORCID 0000-0001-9564-0147
Sumith RoyDepartment of Epidemiology Mailman School of Public Health Columbia University New York NY.ORCID 0000-0002-8887-9835
Bruce J PasterThe Forsyth Institute Cambridge MA.
Ching-Yuan ChenDivision of Periodontics Section of Oral, Diagnostic and Rehabilitation Sciences College of Dental Medicine Columbia University New York NY.
Michael RosenbaumDivision of Molecular Genetics Departments of Pediatrics and Medicine Columbia University New York NY.
Melana YuzefpolskayaDivision of Cardiology Department of Medicine New York Presbyterian HospitalColumbia University New York NY.ORCID 0000-0003-4729-8943
Paolo C ColomboDivision of Cardiology Department of Medicine New York Presbyterian HospitalColumbia University New York NY.ORCID 0000-0003-4977-3285
Moïse DesvarieuxDepartment of Epidemiology Mailman School of Public Health Columbia University New York NY.
Panos N PapapanouDivision of Periodontics Section of Oral, Diagnostic and Rehabilitation Sciences College of Dental Medicine Columbia University New York NY.ORCID 0000-0002-6538-3618
David R JacobsDivision of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN.ORCID 0000-0002-7232-0543
Rob KnightDepartment of Computer Science & Engineering Jacobs School of Engineering University of California San Diego La Jolla CA.ORCID 0000-0002-0975-9019
Ryan T DemmerDivision of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN.ORCID 0000-0003-3429-0379
Columbia University · USUniversity of Minnesota · USNewYork–Presbyterian Hospital · USUniversity of California San Diego · USHarvard University · USInserm · FRNational University of Singapore · SG
Funding
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3MThe Subgingival Microbiome and Impaired Glucose RegulationR01DK102932 · NIDDK · UNIVERSITY OF MINNESOTA · PI DEMMER, RYAN T. · 2015 to 2019
$3.1MPeriodontal Infections and Type 2 Diabetes Mellitus RiskR00DE018739 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DEMMER, RYAN T. · 2010 to 2014
$783kSubgingival microbial community structure and insulin resistanceR21DE022422 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DEMMER, RYAN T. · 2012 to 2013
$432kNHLBI NIH HHS T32 HL007779NIDCR NIH HHS R00 DE018739NIDCR NIH HHS R21 DE022422NIDDK NIH HHS R01 DK102932
Abstract
Background The enterosalivary nitrate-nitrite-nitric oxide (NO
Indexed as
Cardiovascular DiseasesMicrobiotaAdultBacteriaFemaleHumansMaleNitratesNitric OxideNitritesNitrogenNitrogen DioxideRNA, Ribosomal, 16SNitratesNitric OxideNitritesNitrogenNitrogen DioxideRNA, Ribosomal, 16S16S rNA sequencingblood pressureepidemiologyinsulin resistancemetagenomicsnitric oxideoral microbiome
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.