ArticleJournal of the American Heart Association2022
Per-Protocol Versus Intention-to-Treat in Clinical Trials: The Example of GLOBAL-LEADERS Trial.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Self-perceived pain in Hyrax versus other maxillary expansion orthodontic appliances: a systematic review of clinical studies.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Pooled it
- A randomised controlled trial of a lived experience and education-based weight bias intervention for Australian healthcare students.International journal of obesity (2005) · 2026Trial
- Article
- Methods of Analysis in Randomized Noninferiority Trials: Methodological Survey Review Protocol.JMIR research protocols · 2026Article
- Comparing Different As-Treated Approaches: A Methodological Study Using Real-World Data on Psoriasis Treatments.Pharmacoepidemiology and drug safety · 2026Article
- The Use of Estimands in the Design and Analysis of Comparative Effectiveness Trials: The PEPPER Trial.JB & JS open accessArticle
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.