Evidence map›Paper›PMID 35574521›Full record

ArticleAdvanced genetics (Hoboken, N.J.)2022

Social Determinants of Health Factors for Gene-Environment COVID-19 Research: Challenges and Opportunities.

Jimmy Phuong, Naomi O Riches, Charisse Madlock-Brown, Deborah Duran, Luca Calzoni, Juan C Espinoza, Gora Datta, Ramakanth Kavuluru, Nicole G Weiskopf, Cavin K Ward-Caviness and 1 more

Abstract read
In one paragraph

Article in Advanced genetics (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Toward informatics-enabled preparedness for natural hazards to minimize health impacts of climate change.Journal of the American Medical Informatics Association : JAMIA · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jimmy PhuongDivision of Biomedical and Health Informatics University of Washington Seattle WA 98195 USA.ORCID https://orcid.org/0000-0003-0956-8404
Naomi O RichesDepartment of Biomedical Informatics University of Utah School of Medicine Salt Lake City UT 84108-3514 USA.ORCID https://orcid.org/0000-0001-9815-6932
Charisse Madlock-BrownHealth Informatics and Information Management University of Tennessee Health Science Center Memphis TN 38163 USA.ORCID https://orcid.org/0000-0002-3647-1045
Deborah DuranNational Institute on Minority Health and Health Disparities (NIMHD) National Institutes of Health Bethesda MD 20892-5465 USA.
Luca CalzoniNational Institute on Minority Health and Health Disparities (NIMHD) National Institutes of Health Bethesda MD 20892-5465 USA.ORCID https://orcid.org/0000-0002-4066-8617
Juan C EspinozaDepartment of Pediatrics Children's Hospital Los Angeles Los Angeles CA 90015 USA.ORCID https://orcid.org/0000-0003-0513-588X
Gora DattaDepartment of Civil and Environmental Engineering University of California at Berkeley Berkeley CA 94720 USA.ORCID https://orcid.org/0000-0002-7783-296X
Ramakanth KavuluruDivision of Biomedical Informatics Department of Internal Medicine University of Kentucky Lexington KY 40506 USA.ORCID https://orcid.org/0000-0003-1238-9378
Nicole G WeiskopfDepartment of Medical Informatics & Clinical Epidemiology Oregon Health & Science University Portland OR 97239 USA.ORCID https://orcid.org/0000-0003-0365-909X
Cavin K Ward-CavinessCenter for Public Health and Environmental Assessment US Environmental Protection Agency Chapel Hill NC 27514 USA.ORCID https://orcid.org/0000-0002-6322-4349
Asiyah Yu LinNational Human Genome Research Institute (NHGRI) National Institutes of Health Bethesda MD 20892-2152 USA.ORCID https://orcid.org/0000-0003-2620-0345

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
CD2H - The National COVID Cohort Collaborative (N3C) IDeA CTR CollaborationU24TR002306 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CHUTE, CHRISTOPHER G, EICHMANN, DAVID A. · 2017 to 2021
$28.9M
Identifying and understanding drivers of selection bias and information bias in clinical COVID-19 dataR21LM013645 · NLM · OREGON HEALTH & SCIENCE UNIVERSITY · PI WEISKOPF, NICOLE GRAY · 2021 to 2022
$368k
NCATS NIH HHS U24 TR002306NCATS NIH HHS UL1 TR001855NCATS NIH HHS UL1 TR001998NLM NIH HHS R21 LM013645
6 · The paper itself

Abstract

The characteristics of a person's health status are often guided by how they live, grow, learn, their genetics, as well as their access to health care. Yet, all too often, studies examining the relationship between social determinants of health (behavioral, sociocultural, and physical environmental factors), the role of demographics, and health outcomes poorly represent these relationships, leading to misinterpretations, limited study reproducibility, and datasets with limited representativeness and secondary research use capacity. This is a profound hurdle in what questions can or cannot be rigorously studied about COVID-19. In practice, gene-environment interactions studies have paved the way for including these factors into research. Similarly, our understanding of social determinants of health continues to expand with diverse data collection modalities as health systems, patients, and community health engagement aim to fill the knowledge gaps toward promoting health and wellness. Here, a conceptual framework is proposed, adapted from the population health framework, socioecological model, and causal modeling in gene-environment interaction studies to integrate the core constructs from each domain with practical considerations needed for multidisciplinary science.

Indexed as

COVID‐19environmental factorsgenomicsGxEmedical informaticssocial determinant of health

Identifiers

PMID35574521
PMCPMC9087427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.