Evidence map›Paper›PMID 35574449›Full record

ArticleFrontiers in physiology2022

Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications.

Steffen M Recktenwald, Marcelle G M Lopes, Stephana Peter, Sebastian Hof, Greta Simionato, Kevin Peikert, Andreas Hermann, Adrian Danek, Kai van Bentum, Hermann Eichler and 3 more

Abstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
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  6. Unbiased Morphometric Assessment of Red Blood Cell Storage Lesion in the Presence of Shear-Induced Stomatocytes.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
    Article
  7. Shape-Dependent Structural Order of Red Blood Cells.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. The Putative Role of the Transient Receptor Potential Ion Channel of Vanilloid Type 2 in Red Blood Cell Storage Lesions.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Article
  15. Article
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  17. Review
  18. Article
  19. Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Steffen M RecktenwaldExperimental Physics, Saarland University, Saarbruecken, Germany.
Marcelle G M LopesExperimental Physics, Saarland University, Saarbruecken, Germany.
Stephana PeterExperimental Physics, Saarland University, Saarbruecken, Germany.
Sebastian HofExperimental Physics, Saarland University, Saarbruecken, Germany.
Greta SimionatoExperimental Physics, Saarland University, Saarbruecken, Germany.
Kevin PeikertTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
Andreas HermannTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
Adrian DanekNeurologische Klinik und Poliklinik, Ludwig-Maximilians-University, Munich, Germany.
Kai van BentumMVZ Saarpfalz, Homburg, Germany.
Hermann EichlerInstitute for Clinical Hemostaseology and Transfusion Medicine, Saarland University and Saarland University Hospital, Homburg, Germany.
Christian WagnerExperimental Physics, Saarland University, Saarbruecken, Germany.
Stephan QuintExperimental Physics, Saarland University, Saarbruecken, Germany.
Lars KaestnerExperimental Physics, Saarland University, Saarbruecken, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In many medical disciplines, red blood cells are discovered to be biomarkers since they "experience" various conditions in basically all organs of the body. Classical examples are diabetes and hypercholesterolemia. However, recently the red blood cell distribution width (RDW), is often referred to, as an unspecific parameter/marker (e.g., for cardiac events or in oncological studies). The measurement of RDW requires venous blood samples to perform the complete blood cell count (CBC). Here, we introduce Erysense, a lab-on-a-chip-based point-of-care device, to evaluate red blood cell flow properties. The capillary chip technology in combination with algorithms based on artificial neural networks allows the detection of very subtle changes in the red blood cell morphology. This flow-based method closely resembles

Indexed as

artificial capillaryerythrocytehemodiafiltrationmicrofluidicsneuroacanthocytosis syndromephase diagramred cell storageshape classification

Identifiers

PMID35574449
PMCPMC9091344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.