ReviewFrontiers in physiology2022
Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Therapeutic potential of dental follicle-derived stem cells and gold nanoparticles on osteoarthritic temporomandibular joint in guinea pigs (randomized prospective study).BMC oral health · 2026Article
- Temporomandibular Joint Osteoarthritis Modeling Methods' Efficacy in SD Rats: A Scoping Review.Oral diseases · 2026Article
- Article
- Functional orthopedic treatment for mandibular asymmetry in a giant panda with amputation.The Angle orthodontist · 2026Article
- Association of single nucleotide polymorphisms in FILIP1-SENP6 and FTO with temporomandibular joint osteoarthritis: clinical and in silico study.Scientific reports · 2026Article
- Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis.Osteoarthritis and cartilage · 2026Article
- Article
- USP34 attenuates cartilage degradation in temporomandibular joint osteoarthritis by ANT1-mediated mitophagy.JBMR plus · 2026Article
- A reproducible mouse model of TMJ anterior disc displacement.JBMR plus · 2026Article
- Goat temporomandibular joint osteochondral defects for future regenerative studies of osteoarthritis-like degeneration.PloS one · 2026Article
- Eosinophils-Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF-β Pathway Mediated by Anxa1 Binding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Identification of Synovial Lymphatics in the TMJ and their Roles in Arthritis and Pain.Research square · 2025Article
- Loss of SCRG1 in chondrocytes inhibits osteoarthritis by promoting autophagy activity in the temporomandibular joint through inhibition of neurokine receptors.Journal of oral & facial pain and headache · 2025Article
- Mapping cell diversity and dynamics in inflammatory temporomandibular joint osteoarthritis with pain at single-cell resolution.JCI insight · 2025Article
- Osteoarthritis-like changes in rat temporomandibular joint induced by unilateral anterior large overjet treatment.Scientific reports · 2025Article
- A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis.Frontiers in immunology · 2025Article
- Different effects of abnormal mechanical stress on temporomandibular joint cartilage, subchondral bone, and discs.Frontiers in physiology · 2025Review
- Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice.Journal of visualized experiments : JoVE · 2024Article
- Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis.BMC musculoskeletal disorders · 2024Article
- Long-term haplodeficency of DSPP causes temporomandibular joint osteoarthritis in mice.BMC oral health · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective tools for early diagnosis and disease-modifying therapies has been hindered. Animal models play a key role in understanding the pathological process of diseases and evaluating new therapeutic interventions. Although some similarities in disease processes between animals and humans are known, no one animal model is sufficient for studying all characteristics of TMJOA, as each model has different translatability to human clinical conditions. For the past 4 decades, TMJOA animal models have been studied by numerous researchers and can be broadly divided into induced, naturally occurring, and genetically modified models. The induced models can be divided into invasive models (intra-articular injection and surgical induction) or non-invasive models (mechanical loading, high-fat diet, and sleep deprivation). Different types of animal models simulate different pathological expressions of TMJOA and have their unique characteristics. Currently, mice, rats, and rabbits are commonly used in the study of TMJOA. This review sought to provide a general description of current experimental models of TMJOA and assist researchers in selecting the most appropriate models for different kinds of research.
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