Evidence map›Paper›PMID 35574180›Full record

ArticleToxicon: X2022

Evaluation of lethality and cytotoxic effects induced by

Ernest Z Manson, Mutinda C Kyama, Joseph K Gikunju, Josephine Kimani, James H Kimotho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicon: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ernest Z MansonInstitute for Basic Sciences, Technology & Innovation, Pan African University, Nairobi, Kenya.
Mutinda C KyamaDepartment of Medical Laboratory Science, College of Health Sciences, Jomo Kenyatta University of Agriculture & Technology, Nairobi, Kenya.
Joseph K GikunjuDepartment of Medical Laboratory Science, College of Health Sciences, Jomo Kenyatta University of Agriculture & Technology, Nairobi, Kenya.
Josephine KimaniDepartment of Biochemistry, College of Health Sciences, Jomo Kenyatta University of Agriculture & Technology, Nairobi, Kenya.
James H KimothoKenya Medical Research Institute, Nairobi, Kenya.
Jomo Kenyatta University of Agriculture and Technology · KEKenya Medical Research Institute · KEPan Africa Christian University · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutralization of lethality in mice model at the preclinical level has been established by the World Health Organization as the gold standard for the evaluation of antivenom efficacy. The assessment of the neutralization profiles of antivenoms helps to discern the efficacy or otherwise of these antivenoms at neutralizing the toxic effects induced by medically significant snake venoms. However, for many antivenoms, information on their preclinical efficacy remains limited. Therefore, to strengthen global efforts at reducing the impact of snakebite envenoming, the provision of information on the preclinical efficacy of antivenoms, especially in parts of the world where antivenom availability and accessibility is problematic, including sub-Saharan Africa is crucial. This study presents the lethal and toxic activities of

Indexed as

AntivenomsMedian lethal doseMinimum edema-forming doseMinimum necrotizing doseNaja asheiPreclinical efficacy

Identifiers

PMID35574180
PMCPMC9096668
OpenAlexW4225429061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.