ArticleBioactive materials2023
3D printing of bio-instructive materials: Toward directing the cell.
Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Decoding triple negative breast cancer bone metastasis: from 3D bioprinted models to clinical translation.Journal of nanobiotechnology · 2026Review
- Stimuli-responsive 4D-bioprinted constructs for musculoskeletal tissue regeneration: Shape-morphing mechanisms, cell-laden bioink engineering, and preclinical outcomes.Regenerative therapy · 2026Review
- Application of PLCL as a biodegradable polymer in biomedical engineering.Journal of materials science. Materials in medicine · 2026Review
- Cell encapsulated biomaterials for translational medicine.Bioactive materials · 2026Review
- Reimagining periodontal regeneration: smart biomaterials for a complex tissue landscape.Regenerative biomaterials · 2026Review
- Rapid endothelialization of printed vascular grafts by perivascular niche-circulating endothelial progenitors crosstalk.Nature communications · 2025Article
- Implications of Tissue Engineering for Tendon Repair and Regeneration.Journal of functional biomaterials · 2025Review
- From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function.Expert reviews in molecular medicine · 2025Review
- 4D-printed microdevices for spatiotemporal detection of ctDNA and miRNA in pancreatic cancer: an in-depth review.Medical oncology (Northwood, London, England) · 2025Review
- An Injectable BMP-2-Releasing Porous Hydrogel Regulating the Paracrine Effects of ADSCs Promotes Tendon-to-Bone Healing in Rotator Cuff Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Beyond natural silk: Bioengineered silk fibroin for bone regeneration.Materials today. Bio · 2025Review
- 3D-Printed Cell-Instructive Scaffolds Based onACS biomaterials science & engineering · 2025Article
- Nanotopographical Features of Polymeric Nanocomposite Scaffolds for Tissue Engineering and Regenerative Medicine: A Review.Biomimetics (Basel, Switzerland) · 2025Review
- Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.Annual review of biomedical engineering · 2025Review
- Integrating melt electrowriting (MEW) PCL scaffolds with fibroblast-laden hydrogel toward vascularized skin tissue engineering.Materials today. Bio · 2025Article
- Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds.Advanced healthcare materials · 2025Article
- A Fast Slicing Method for Colored Models Based on Colored Triangular Prism and OpenGL.Micromachines · 2025Article
- Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation.Frontiers in bioengineering and biotechnology · 2025Review
- Concept and Evolution in 3D Printing for Excellence in Healthcare.Current medicinal chemistry · 2025Review
- 3D bioprinting of high-performance hydrogel with in-situ birth of stem cell spheroids.Bioactive materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance. 3D printing is a powerful technique to create highly complex and multicomponent structures with well-defined architecture and composition. In this review paper, we explore extrusion-based 3D printing methods (EBP, i.e., Near Field Electrospinning (NFES), Melt Electrowriting (MEW), Fused Deposition Modeling (FDM), and extrusion bioprinting) in terms of their ability to produce scaffolds with bio-instructive properties. These material systems provide spatio-temporal guidance for cells, allowing controlled tissue regeneration and maturation. Multiple physical and biochemical cues introduced to the EBP scaffolds are evaluated in their ability to direct cell alignment, proliferation, differentiation, specific ECM production, and tissue maturation. We indicate that the cues have different impacts depending on the material system, cell type used, or coexistence of multiple cues. Therefore, they must be carefully chosen based on the targeted application. We propose future directions in bio-instructive materials development, including such concepts as metamaterials, hybrid living materials, and 4D printing. The review gathers the knowledge essential for designing new materials with a controlled cellular response, fabrication of advanced engineered tissue, and developing a better understanding of cell biology, especially in response to the biomaterial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.