Evidence map›Paper›PMID 35574051›Full record

ReviewBioactive materials2023

Smart bioadhesives for wound healing and closure.

Jia Zhu, Honglei Zhou, Ethan Michael Gerhard, Senhao Zhang, Flor Itzel Parra Rodríguez, Taisong Pan, Hongbo Yang, Yuan Lin, Jian Yang, Huanyu Cheng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

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  18. Biomolecular Microneedle Initiates FeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia ZhuDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Honglei ZhouAML, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China.
Ethan Michael GerhardDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Senhao ZhangDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Flor Itzel Parra RodríguezDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Taisong PanSchool of Materials and Energy, State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Hongbo YangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, 215011, PR China.
Yuan LinSchool of Materials and Energy, State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Jian YangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Huanyu ChengDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.

Funding

Wearable, Graphene-based Flexible Sensors for Chronic Monitoring of Venous Thromboembolism for High-Risk PatientsR61HL154215 · NHLBI · ACTUATED MEDICAL, INC. · PI BAGWELL, ROGER BROOKS · 2020 to 2021
$787k
Smart skin grafts for quantitative assessment and treatment of diabetic woundsR21EB030140 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHENG, HUANYU · 2021 to 2021
$620k
NHLBI NIH HHS R61 HL154215NIBIB NIH HHS R21 EB030140
6 · The paper itself

Abstract

The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing, wireless communication, and on-demand treatment capabilities. Bioadhesives with bio-inspired structures and chemicals have shown unprecedented adhesion strengths, as well as tunable optical, electrical, and bio-dissolvable properties. Accelerated wound healing has been achieved via directly released antibacterial and growth factors, material or drug-induced host immune responses, and delivery of curative cells. Most recently, the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives, allowing real-time sensing of the physiological conditions (e.g., pH, temperature, uric acid, glucose, and cytokine) with iterative feedback for drastically enhanced, stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged inflammation. Despite rapid advances in the burgeoning field, challenges still exist in the design and fabrication of integrated systems, particularly for chronic wounds, presenting significant opportunities for the future development of next-generation smart materials and systems.

Indexed as

Closed-loop systemImmunomodulatory bioadhesivesMechanically/electrically active bioadhesivesOn-demand treatmentsSmart bioadhesivesWound healing and closure

Identifiers

PMID35574051
PMCPMC9062426

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.