ArticleFrontiers in endocrinology2022
Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight/Obesity Within the Frame of the PREDIMED-Plus Study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies.BMC medicine · 2023Pooled it
- Metabolic plasticity of the gut microbiome in response to diets differing in glycemic load in a randomized, crossover, controlled feeding study.The American journal of clinical nutrition · 2025Trial
- Weight, habitual fibre intake, and microbiome composition predict tolerance to fructan supplementation.International journal of food sciences and nutrition · 2024Trial
- Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction.Nature communications · 2024Trial
- Phage-microbe dynamics after sterile faecal filtrate transplantation in individuals with metabolic syndrome: a double-blind, randomised, placebo-controlled clinical trial assessing efficacy and safety.Nature communications · 2023Trial
- Intestinal Microbiome, Fecal Fermentation Profile, and Health Indices in HIV-Positive Men Versus Normal Controls Without HIV.Nutrients · 2026Article
- Structural and functional characteristics of faecal, vaginal and colostrum microbiota in high-yielding sows.Microbial genomics · 2026Article
- Integrative profiling of gut microbiome, bacteriophagenome, and predicted metabolome in obese adults: novel insights into intervention targets.BMC microbiology · 2026Article
- Dual-approach analysis of gut microbiome in patients with type 1 diabetes and diabetic kidney disease.Annals of medicine · 2025Article
- The Influence of an AI-Driven Personalized Nutrition Program on the Human Gut Microbiome and Its Health Implications.Nutrients · 2025Article
- [Relationship Between Different Traditional Chinese Medicine Syndrome Types and Gut Microbiota in Patients With Type 2 Diabetes Mellitus].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota.NPJ biofilms and microbiomes · 2025Article
- Comparative assessment of phenotypic markers in patients with chronic inflammation: Differences on Bifidobacterium concerning liver status.European journal of clinical investigation · 2025Article
- Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.Frontiers in microbiology · 2025Article
- Fasting elicits gut microbiome signature changes that extend to type 1 diabetes patients.Frontiers in endocrinology · 2025Article
- Major depletion of insulin sensitivity-associated taxa in the gut microbiome of persons living with HIV controlled by antiretroviral drugs.BMC medical genomics · 2024Article
- Article
- Living Conditions Alter Ketogenic Diet-induced Metabolic Consequences in Mice through Modulating Gut Microbiota.Phenomics (Cham, Switzerland) · 2024Article
- High fat diet increases the severity of collagen-induced arthritis in mice by altering the gut microbial community.Advances in rheumatology (London, England) · 2024Article
- Causal effect between gut microbiota and metabolic syndrome in European population: a bidirectional mendelian randomization study.Cell & bioscience · 2024Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: An altered gut microbiota has been associated with insulin resistance, a metabolic dysfunction consisting of cellular insulin signaling impairment. The aim of the present study is to determine the taxonomic and functional fecal microbiota signatures associated with HOMA-IR index in a population with high cardiovascular risk. Methods: A total of 279 non-diabetic individuals (55-75 years aged) with overweight/obesity and metabolic syndrome were stratified according to tertiles of HOMA-IR index. Blood biochemical parameters, anthropometric measurements and fecal samples were collected at baseline. Fecal microbial DNA extraction, 16S amplicon sequencing and bioinformatics analysis were performed. Results: Conclusions: Specific taxonomic and functional fecal microbiota signatures associated with insulin resistance were identified in a non-diabetic population with overweight/obesity at high cardiovascular risk. These findings suggest that tailoring therapies based on specific fecal microbiota profiles could be a potential strategy to improve insulin sensitivity.
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