Evidence map›Paper›PMID 35573940›Full record

ArticleFrontiers in pediatrics2022

Number of Episodes Can Be Used as a Disease Activity Measure in Familial Mediterranean Fever.

David Piskin, Zehra Serap Arici, Dilek Konukbay, Micol Romano, Balahan Makay, Nuray Ayaz, Yelda Bilginer, Roberta A Berard, Hakan Poyrazoglu, Ozgur Kasapcopur and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 2 countries.

David PiskinChildren's Health Research Institute, Lawson Health Research Institute, London, ON, Canada.
Zehra Serap AriciClinical Epidemiology, McMaster University, Hamilton, ON, Canada.
Dilek KonukbayGulhane Faculty of Nursing, University of Health Sciences, Ankara, Turkey.
Micol RomanoDivision of Paediatric Rheumatology, Department of Paediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Balahan MakayPediatric Rheumatology Unit, Dokuz Eylül University, ízmir, Turkey.
Nuray AyazDepartment of Pediatric Rheumatology, Istanbul University Medical School, Istanbul, Turkey.
Yelda BilginerPediatric Rheumatology Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Roberta A BerardChildren's Health Research Institute, Lawson Health Research Institute, London, ON, Canada.
Hakan PoyrazogluDivision of Rheumatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Ozgur KasapcopurPediatric Rheumatology Unit, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Ronald M LaxerThe Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Kathy SpeechleyChildren's Health Research Institute, Lawson Health Research Institute, London, ON, Canada.
Erkan DemirkayaChildren's Health Research Institute, Lawson Health Research Institute, London, ON, Canada.
Western University · CAIstanbul University · TRChildren’s Health Research Institute · CADokuz Eylül University · TRErciyes University · TRHacettepe University · TRLawson Health Research Institute · CAMcMaster University · CASağlık Bilimleri Üniversitesi · TRSickKids Foundation · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the number of episodes in the past 12 months as an indicator of the overall disease activity status in Familial Mediterranean fever (FMF). Methods: In this cross-sectional study, patients were recruited from tertiary pediatric hospitals. Demographic data, main clinical symptoms of the episodes, treatment modalities, and genetic mutations were recorded. The patients were grouped as no episodes (Group 1), 1-4 episodes (Group 2), and more than 4 episodes (Group 3) according to the number of episodes in the past 12 months. The Pediatric Quality Life Inventory (PedsQL), the Children's Depression Inventory (CDI), and the Wong-Baker FACES Pain Rating Scale (FACES) scores were compared between groups. Concurrent validity between the number of episodes and the patient-reported outcome measures (PROMs) was assessed using Spearman's rank correlation coefficient (ρ). Results: A total of 239 patients were included. There were 74 patients (31%) in Group 1, 99 (41.4%) in Group 2, and 66 (27.6%) in Group 3. Groups were similar according to age, age at diagnosis, gender, consanguinity, family history, history of amyloidosis, clinical symptoms, and in terms of allele frequency ( Conclusion: The number of episodes was positively and moderately correlated with patient- and parent-reported outcomes in our cohort. The number of episodes in patients with FMF can be used as a single measure to assess disease activity.

Indexed as

convergent validitydisease activityFamilial Mediterranean feverpatient reported outcomesquality of life

Identifiers

PMID35573940
PMCPMC9091585
OpenAlexW4224923003

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.