Evidence map›Paper›PMID 35573928›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2021

On Interpretability of Artificial Neural Networks: A Survey.

Feng-Lei Fan, Jinjun Xiong, Mengzhou Li, Ge Wang

Registry-linked trialAbstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06878469 (SIMPLIF-AI), which is not on this map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06878469 narecruitingnot on this mapstarted 2025, after this paper: background citation

SIMPLIF-AI: SIMPLIFication and Standardization of Care Pathways for Patients With Rare Brain Tumors Through Artificial Intelligence

TypeinterventionalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2025 to 2027Enrolled200ConditionsBrain TumorsArmsRehaCom
3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
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  12. [Research progress on deep learning-based computer-aided diagnosis of thyroid nodules using ultrasound imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
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  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Feng-Lei FanDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Jinjun XiongIBM Thomas J. Watson Research Center, Yorktown Heights, NY, 10598, USA.
Mengzhou LiDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Ge WangDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.

Funding

Cardiac CT DebloomingR01HL151561 · NHLBI · GENERAL ELECTRIC GLOBAL RESEARCH CTR · PI BUDOFF, MATTHEW J, DE MAN, BRUNO · 2020 to 2023
$3.8M
Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver MetastasesR01CA233888 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHUN, YUN SHIN, DO, RICHARD KINH GIAN · 2019 to 2023
$3.7M
In vivo Macroscopic Fluorescence Lifetime Molecular Optical ImagingR01CA250636 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI BARROSO, MARGARIDA, INTES, XAVIER · 2020 to 2023
$2.9M
Photon-counting X-ray and Optical Tomography for Preclinical Cancer ResearchR01CA237267 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI BARROSO, MARGARIDA, INTES, XAVIER · 2019 to 2023
$2.9M
Life time imaging with pulsed x-ray based x-ray luminescence computed tomographyR01EB026646 · NIBIB · UNIVERSITY OF CALIFORNIA, MERCED · PI LI, CHANGQING · 2018 to 2021
$2.6M
NCI NIH HHS R01 CA233888NCI NIH HHS R01 CA237267NCI NIH HHS R01 CA250636NHLBI NIH HHS R01 HL151561NIBIB NIH HHS R01 EB026646
6 · The paper itself

Abstract

Deep learning as represented by the artificial deep neural networks (DNNs) has achieved great success recently in many important areas that deal with text, images, videos, graphs, and so on. However, the black-box nature of DNNs has become one of the primary obstacles for their wide adoption in mission-critical applications such as medical diagnosis and therapy. Because of the huge potentials of deep learning, increasing the interpretability of deep neural networks has recently attracted much research attention. In this paper, we propose a simple but comprehensive taxonomy for interpretability, systematically review recent studies in improving interpretability of neural networks, describe applications of interpretability in medicine, and discuss possible future research directions of interpretability, such as in relation to fuzzy logic and brain science.

Indexed as

Deep learninginterpretabilityneural networkssurvey

Identifiers

PMID35573928
PMCPMC9105427

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.