Evidence map›Paper›PMID 35573675›Full record

ArticleFrontiers in cell and developmental biology2022

Actin Dynamics as a Multiscale Integrator of Cellular Guidance Cues.

Abby L Bull, Leonard Campanello, Matt J Hourwitz, Qixin Yang, Min Zhao, John T Fourkas, Wolfgang Losert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Signaling and actin waves at a glance.Journal of cell science · 2025
    Review
  3. Article
  4. A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Nanotopography modulates intracellular excitable systems through cytoskeleton actuation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abby L BullInstitute for Physical Science and Technology, University of Maryland, College Park, MD, United States.
Leonard CampanelloInstitute for Physical Science and Technology, University of Maryland, College Park, MD, United States.
Matt J HourwitzDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, United States.
Qixin YangInstitute for Physical Science and Technology, University of Maryland, College Park, MD, United States.
Min ZhaoInstitute for Regenerative Cures, Department of Ophthalmology and Vision Science, Department of Dermatology, School of Medicine, University of California, Davis, Davis, CA, United States.
John T FourkasInstitute for Physical Science and Technology, University of Maryland, College Park, MD, United States.
Wolfgang LosertInstitute for Physical Science and Technology, University of Maryland, College Park, MD, United States.

Funding

Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical SignalsR01EY019101 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZHAO, MIN · 2010 to 2023
$5.2M
NEI NIH HHS R01 EY019101
6 · The paper itself

Abstract

Migrating cells must integrate multiple, competing external guidance cues. However, it is not well understood how cells prioritize among these cues. We investigate external cue integration by monitoring the response of wave-like, actin-polymerization dynamics, the driver of cell motility, to combinations of nanotopographies and electric fields in neutrophil-like cells. The electric fields provide a global guidance cue, and approximate conditions at wound sites

Indexed as

actin dynamicsactin polymerizationdirectional cell migrationelectrotaxisesotaxisgalvanotaxismultiple directional cuesneutrophil

Identifiers

PMID35573675
PMCPMC9092214

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.