Evidence map›Paper›PMID 35573459›Full record

ArticleCurrent research in structural biology2022

FOXO transcription factors differ in their dynamics and intra/intermolecular interactions.

Emil Spreitzer, T Reid Alderson, Benjamin Bourgeois, Loretta Eggenreich, Hermann Habacher, Greta Brahmersdorfer, Iva Pritišanac, Pedro A Sánchez-Murcia, Tobias Madl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in structural biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. The link of FOXO1 and FOXO4 transcription factors to development of the lens.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. The role of mechanosignaling in the control of myocardial mass.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  7. Methods to Study Structure and Dynamics of FOXO Proteins.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emil SpreitzerGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
T Reid AldersonGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Benjamin BourgeoisGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Loretta EggenreichGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Hermann HabacherGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Greta BrahmersdorferGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Iva PritišanacGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Pedro A Sánchez-MurciaDivision of Physiological Chemistry, Otto-Loewi Research Center, Medical University of Graz, Graz, Austria.
Tobias MadlGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.

Funding

Austrian Science Fund FWF W 1226
6 · The paper itself

Abstract

Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families. Among them, the Forkhead box O (FOXO) family contains transcription factors crucial for cellular homeostasis, longevity and response to stress. The dysregulation of FOXO signaling is linked to drug resistance in cancer therapy or cellular senescence, however, selective drugs targeting FOXOs are limited, thus knowledge about structure and dynamics of FOXO proteins is essential. Here, we provide an extensive study of structure and dynamics of all FOXO family members. We identify residues accounting for different dynamic and structural features. Furthermore, we show that the auto-inhibition of FOXO proteins by their C-terminal trans-activation domain is conserved throughout the family and that these interactions are not only possible intra-, but also inter-molecularly. This indicates a model in which FOXO transcription factors would modulate their activities by interacting mutually.

Indexed as

CSP, chemical shift perturbationDBE, DAF-16 family member binding elementFOXO, Forkhead box OIGF-1, insulin-like growth factorIRE, insulin response elementJNK, Jun N terminal kinaseMD, molecular dynamicsMolecular dynamicsNMR, nuclear magnetic resonanceNMR spectroscopyNOE, nuclear Overhauser effectPP2A, protein phosphatase 2AProtein dynamicsRMSD, root-mean -square deviationRMSF, root-mean-square-fluctuationSGK, serum and glucocorticoid-induced kinaseSpin relaxationTAD, transactivation domainTF, transcription factorTranscription activation domainTranscription factors

Identifiers

PMID35573459
PMCPMC9097636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.