Evidence map›Paper›PMID 35573422›Full record

ArticleCase reports in transplantation2022

Catastrophic Antiphospholipid Syndrome after Orthotopic Liver Transplant.

R Okeke, J Lok, R Wells, M Wycoff, A Engelhardt, J Bettag, C O'Leary, T Hallcox, M Nazzal

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

R OkekeSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0002-7185-9571
J LokSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0001-7633-1760
R WellsSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0002-8962-7429
M WycoffSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0002-3710-6314
A EngelhardtSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0002-6529-0382
J BettagSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0003-2712-9499
C O'LearySaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0003-4591-4060
T HallcoxSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0002-7289-8580
M NazzalSaint Louis University, St. Louis MO 63108, USA.ORCID https://orcid.org/0000-0001-6029-6585
Saint Louis University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Catastrophic antiphospholipid syndrome (CAPS) is an autoimmune thrombogenic disorder of small and large vessels caused by autoantibodies against phospholipids and phospholipid-binding proteins. This severe form of antiphospholipid syndrome (APS) presents clinically with simultaneous life-threatening multiorgan thrombosis and the presence of two or more persistent antiphospholipid antibodies (APL) confirmed on testing 12 weeks apart. Conclusion: Our patient provided a standard presentation of CAPS with abnormal pretransplant levels of antinuclear antibodies (ANA). Although there have been studies investigating the relationship between anticardiolipin antibodies and lupus anticoagulants and APS, the relationship between pretransplant positive ANA or antimitochondrial antibodies (AMA) and CAPS has yet to be explored. Further studies will be needed to determine the significance of these antibodies. We recommend preoperative APL testing for patients with positive ANA and AMA at preliver transplant presentation.

Identifiers

PMID35573422
PMCPMC9098363
OpenAlexW4229042824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.