ArticleFrontiers in neuroscience2022
Imaging Genetic Based Mediation Analysis for Human Cognition.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- High-dimensional causal mediation analysis by partial sum statistic and sample splitting strategy in imaging genetics application.Bioinformatics (Oxford, England) · 2025Article
- S-GMAS: Genome-Wide Mediation Analysis With Brain Subcortical Shape Mediators.Human brain mapping · 2025Article
- High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy.BioData mining · 2025Article
- Computational reconstruction of evolutionary selection in human brain networks.Frontiers in neuroinformatics · 2025Article
- Article
- Mediation analysis in longitudinal study with high-dimensional methylation mediators.Briefings in bioinformatics · 2024Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain connectome maps the structural and functional connectivity that forms an important neurobiological basis for the analysis of human cognitive traits while the genetic predisposition and our cognition ability are frequently found in close association. The issue of how genetic architecture and brain connectome causally affect human behaviors remains unknown. To seek for the potential causal relationship, in this paper, we carried out the causal pathway analysis from single nucleotide polymorphism (SNP) data to four common human cognitive traits, mediated by the brain connectome. Specifically, we selected 942 SNPs that are significantly associated with the brain connectome, and then estimated the direct and indirect effect on the human traits for each SNP. We found out that a majority of the selected SNPs have significant direct effects on human traits and discussed the trait-related brain regions and their implications.
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