Evidence map›Paper›PMID 35573272›Full record

ArticleMonatshefte fur chemie2022

Spectroscopic analysis of 2-(5-mercapto-1,3,4-oxadiazol-2-yl)-6-methylquinolin-4-ol binding to blood plasma albumin.

Karine R Grigoryan, Hasmik A Shilajyan, Ashkhen Zatikyan, Iskuhi Aleksanyan, Lilit Hambardzumyan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Monatshefte fur chemie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Karine R GrigoryanLaboratory of Physical Chemistry, Chemistry Research Center, YSU, Yerevan, Armenia.ORCID 0000-0001-6201-6540
Hasmik A ShilajyanLaboratory of Physical Chemistry, Chemistry Research Center, YSU, Yerevan, Armenia.
Ashkhen ZatikyanLaboratory of Physical Chemistry, Chemistry Research Center, YSU, Yerevan, Armenia.
Iskuhi AleksanyanLaboratory of Organic Chemistry, Chemistry Research Center, YSU, Yerevan, Armenia.
Lilit HambardzumyanLaboratory of Organic Chemistry, Chemistry Research Center, YSU, Yerevan, Armenia.
Yerevan State University · AMInstitute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry · AM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Binding of 2-(5-mercapto-1,3,4-oxadiazol-2-yl)-6-methylquinolin-4-ol (C1), a biologically active substance, to bovine blood plasma albumin (BSA) at 293, 298, and 303 K was studied using fluorescence (steady state, synchronous, excitation/emission matrix) and FT-IR spectroscopy methods. The experimental results showed that C1 causes fluorescence quenching of BSA through both static and dynamic quenching mechanisms. The thermodynamic parameters, enthalpy and entropy change, for the static quenching were calculated to be - 35.73 kJ mol Graphical abstract:

Indexed as

BindingBovine serum albuminFluorescenceIR spectroscopyQuinoline

Identifiers

PMID35573272
PMCPMC9084270
OpenAlexW4229449536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.