Evidence map›Paper›PMID 35573139›Full record

ArticleFrontiers in dental medicine2022

Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries.

Mairobys Socorro, Priyanka Hoskere, Catherine Roberts, Lyudmila Lukashova, Kostas Verdelis, Elia Beniash, Dobrawa Napierala

Open access · goldAbstract read
In one paragraph

Article in Frontiers in dental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Review
  4. JBMR plus · 2026
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mairobys SocorroCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, United States.
Priyanka HoskereCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, United States.
Catherine RobertsCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, United States.
Lyudmila LukashovaCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, United States.
Kostas VerdelisCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, United States.
Elia BeniashCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, United States.
Dobrawa NapieralaCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, United States.
University of Pittsburgh · USMcGowan Institute for Regenerative Medicine · US

Funding

Transcriptional Regulation of Dentin MineralizationR01DE023083 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAPIERALA, DOBRAWA · 2014 to 2018
$1.9M
Phosphate signaling in biomineralizationR01AR074981 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAPIERALA, DOBRAWA · 2019 to 2023
$1.7M
Role of Mineralization-Regulating Transcription Factors in Susceptibility to Dental CariesF32DE029096 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SOCORRO, MAIROBYS · 2020 to 2022
$223k
NIAMS NIH HHS R01 AR074981NIDCR NIH HHS F32 DE029096NIDCR NIH HHS R01 DE023083
6 · The paper itself

Abstract

Dental caries is the most common chronic disease in children and adults worldwide. The complex etiology of dental caries includes environmental factors as well as host genetics, which together contribute to inter-individual variation in susceptibility. The goal of this study was to provide insights into the molecular pathology underlying increased predisposition to dental caries in trichorhinophalangeal syndrome (TRPS). This rare inherited skeletal dysplasia is caused by mutations in the

Indexed as

conditional knockout micedental cariesmineralizationodontoblaststrichorhinophalangeal syndrome

Identifiers

PMID35573139
PMCPMC9106314
OpenAlexW4223616681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.