Evidence map›Paper›PMID 35572785›Full record

ArticleJournal of mass spectrometry and advances in the clinical lab2022

Simultaneous determination of vitamin D metabolites 25(OH)D

Shan Xu, Rui Ni, Lihong Lv, Rui Chen, Yao Chen, Fengjiao Huang, Zhiru Xu

Open access · goldAbstract read
In one paragraph

Article in Journal of mass spectrometry and advances in the clinical lab, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Shan XuThe Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.
Rui NiNational Pharmaceutical Engineering Research Center, 200437 Shanghai, China.
Lihong LvState Key Lab. of New Drug and Pharmaceutical Process/Shanghai Professional and Technical Service Center for Biological Material Druggability Evaluation, Shanghai Institute of Pharmaceutical Industry, 200437 Shanghai, China.
Rui ChenState Key Lab. of New Drug and Pharmaceutical Process/Shanghai Professional and Technical Service Center for Biological Material Druggability Evaluation, Shanghai Institute of Pharmaceutical Industry, 200437 Shanghai, China.
Yao ChenState Key Lab. of New Drug and Pharmaceutical Process/Shanghai Professional and Technical Service Center for Biological Material Druggability Evaluation, Shanghai Institute of Pharmaceutical Industry, 200437 Shanghai, China.
Fengjiao HuangDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China.
Zhiru XuState Key Lab. of New Drug and Pharmaceutical Process/Shanghai Professional and Technical Service Center for Biological Material Druggability Evaluation, Shanghai Institute of Pharmaceutical Industry, 200437 Shanghai, China.
Shanghai Institute of Pharmaceutical Industry · CNFirst Affiliated Hospital of Zhengzhou University · CNNational Engineering Research Center for Nanotechnology · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although measurement of 25(OH)D Methods: Samples were purified from 250 µL human plasma. Chromatography was performed on an analytical column, under gradient conditions using a mobile phase consisting of methanol-lithium acetate. The mass detector was operated in positive multiple reaction monitoring mode. The established method was validated according to the guidance issued by ICH and FDA. Furthermore, a clinical study was performed using this method to detect the plasma concentrations of 1α,25(OH) Results and conclusion: The method was acceptably linear over the concentration ranges of 20-1200 pg/mL for 1α,25(OH)

Indexed as

1α1α,25(OH)2D3, 1α,25-dihydroxy vitamin D325(OH)2D325(OH)D325(OH)D3, 25-hydroxyvitamin D3BSA, bovine serum albuminESI, electrospray ionizationFDA, Food and Drug AdministrationICH, International Council on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human UseIS, internal standardLC-MS/MSLC-MS/MS, liquid chromatography tandem mass spectrometryLLE, liquid liquid extractionMRM, multiple reaction monitoringm/z, mass-to-charge ratiosPharmacokineticsPlasmaPPT, protein precipitationSPE, solid phase extractionVD, vitamin D

Identifiers

PMID35572785
PMCPMC9093011
OpenAlexW4224312492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.