Evidence map›Paper›PMID 35572712›Full record

ArticleFrontiers in microbiology2022

Association Between Human Gut Microbiome and N-Glycan Composition of Total Plasma Proteome.

Vyacheslav A Petrov, Sodbo Zh Sharapov, Lev Shagam, Arina V Nostaeva, Marija Pezer, Dalin Li, Maja Hanić, Dermot McGovern, Edouard Louis, Souad Rahmouni and 3 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vyacheslav A PetrovUnit of Animal Genomics, Grappe Interdisciplinaire de Génoprotéomique Appliquée-Institute, University of Liège, Liège, Belgium.
Sodbo Zh SharapovLaboratory of Glycogenomics, Institute of Cytology and Genetics, Novosibirsk, Russia.
Lev ShagamCentral Research Laboratory, Ministry of Healthcare of Russian Federation, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Tomsk, Russia.
Arina V NostaevaLaboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia.
Marija PezerGenos Ltd., Zagreb, Croatia.
Dalin LiCedars-Sinai Medical Center, The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, CA, United States.
Maja HanićGlycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
Dermot McGovernCedars-Sinai Medical Center, The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, CA, United States.
Edouard LouisLaboratory of Translational Gastroenterology, Grappe Interdisciplinaire de Génoprotéomique Appliquée-Institute, University of Liège, Liège, Belgium.
Souad RahmouniCentral Research Laboratory, Ministry of Healthcare of Russian Federation, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Tomsk, Russia.
Gordan LaucGlycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
Michel GeorgesCentral Research Laboratory, Ministry of Healthcare of Russian Federation, Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Tomsk, Russia.
Yurii S AulchenkoLaboratory of Glycogenomics, Institute of Cytology and Genetics, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Being one of the most dynamic entities in the human body, glycosylation of proteins fine-tunes the activity of the organismal machinery, including the immune system, and mediates the interaction with the human microbial consortium, typically represented by the gut microbiome. Using data from 194 healthy individuals, we conducted an associational study to uncover potential relations between the gut microbiome and the blood plasma N-glycome, including N-glycome of immunoglobulin G. While lacking strong linkages on the multivariate level, we were able to identify associations between alpha and beta microbiome diversity and the blood plasma N-glycome profile. Moreover, for two bacterial genera, namely,

Indexed as

16S sequencingBilophilaIgG N-glycomemucosal microbiomeplasma N-glycome

Identifiers

PMID35572712
PMCPMC9100934

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.