Evidence map›Paper›PMID 35572588›Full record

ArticleFrontiers in immunology2022

Specialized Pro-Resolving Mediators Reduce Scarring After Cleft Lip Repair.

Evangelos Papathanasiou, Andrew R Scott, Carroll Ann Trotman, Corinna Beale, Lori Lyn Price, Gordon S Huggins, Yang Zhang, Irene Georgakoudi, Thomas E Van Dyke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Evangelos PapathanasiouDepartment of Periodontology, Tufts University School of Dental Medicine, Boston, MA, United States.
Andrew R ScottDepartment of Otolaryngology - Head & Neck Surgery, Tufts University School of Medicine, Boston, MA, United States.
Carroll Ann TrotmanCollege of Dentistry, The Ohio State University, Columbus, OH, United States.
Corinna BealeTufts Comparative Medicine Services, Tufts University, Boston, MA, United States.
Lori Lyn PriceTufts Clinical and Translational Science Institute, Tufts University, Boston, MA, United States.
Gordon S HugginsMolecular Cardiology Research Institute and Cardiology Division, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, United States.
Yang ZhangDepartment of Biomedical Engineering, Tufts University School of Engineering, Medford, MA, United States.
Irene GeorgakoudiDepartment of Biomedical Engineering, Tufts University School of Engineering, Medford, MA, United States.
Thomas E Van DykeCenter for Clinical and Translational Research, Forsyth Institute, Cambridge, MA, United States.
Tufts University · USInstitute of Clinical Research · USNovant Health Forsyth Medical Center · USThe Ohio State University · USTufts Medical Center · US

Funding

Tufts Clinical and Translational Science Institute (Pilot Supplement)UL1TR002544 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2018 to 2022
$50.2M
Mechanisms of Resolvin E1 in Periodontal RegenerationR01DE025020 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI GUASTALDI, FERNANDO, VAN DYKE, THOMAS ELLIOTT · 2015 to 2023
$4.9M
Targeting Surgeons Decision-Making for Lip SurgeryU01DE024503 · NIDCR · TUFTS UNIVERSITY BOSTON · PI TROTMAN, CARROLL ANN · 2015 to 2020
$2.3M
Specialized Pro-resolving Mediators (SPMs) & scar tissue formation after cleft-lip surgical repairK08DE027119 · NIDCR · TUFTS UNIVERSITY BOSTON · PI PAPATHANASIOU, EVANGELOS · 2018 to 2023
$794k
Acquisition of Leica confocal/multiphoton microscopeS10OD021624 · OD · TUFTS UNIVERSITY MEDFORD · PI GEORGAKOUDI, IRENE · 2016 to 2016
$600k
NCATS NIH HHS UL1 TR002544NIDCR NIH HHS K08 DE027119NIDCR NIH HHS R01 DE025020NIDCR NIH HHS U01 DE024503NIH HHS S10 OD021624
6 · The paper itself

Abstract

Objective: Residual scarring after cleft lip repair surgery remains a challenge for both surgeons and patients and novel therapeutics are critically needed. The objective of this preclinical experimental study was to evaluate the impact of the methyl-ester of pro-resolving lipid mediator lipoxin A Methods: A defect of the lip was surgically created and repaired in eight six-week old New Zealand white rabbits to simulate human cleft lip scars. Rabbits were randomly assigned to topical application of PBS (control) or 1 ug of LXA Results: Animals treated with LXA Conclusions: These data suggest that LXA

Indexed as

Cleft LipLipoxinsAnimalsCicatrixCollagenHumansRabbitsWound HealingCollagenLipoxinscleft lipcollageninflammationlipoxinsrabbitscarsurgerywound healing

Identifiers

PMID35572588
PMCPMC9094441
OpenAlexW4285745149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.