Evidence map›Paper›PMID 35572581›Full record

ArticleFrontiers in immunology2022

Protein Kinase Inhibitor-Mediated Immunoprophylactic and Immunotherapeutic Control of Colon Cancer.

Silvia Ghione, Cindy Racoeur, Nesrine Mabrouk, Jingxuan Shan, Emma Groetz, Elise Ballot, Caroline Truntzer, Lotfi Chouchane, Frédérique Végran, Catherine Paul and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Silvia GhioneLaboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.
Cindy RacoeurLaboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.
Nesrine MabroukLaboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.
Jingxuan ShanGenetic Intelligence Laboratory, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Emma GroetzLaboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.
Elise BallotPlateforme de Transfert en Biologie Cancérologique, Centre Georges François Leclerc, Dijon, France.
Caroline TruntzerPlateforme de Transfert en Biologie Cancérologique, Centre Georges François Leclerc, Dijon, France.
Lotfi ChouchaneGenetic Intelligence Laboratory, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Frédérique VégranPlateforme de Transfert en Biologie Cancérologique, Centre Georges François Leclerc, Dijon, France.
Catherine PaulLaboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.
Stéphanie PlenchetteLaboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.
Ali BettaiebLaboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.
Université de Bourgogne · FRÉcole Pratique des Hautes Études · FRUniversité Bourgogne Franche-Comté · FRWeill Cornell Medical College in Qatar · QACentre de recherche Translationnelle en Médecine moléculaire · FRCentre Georges François Leclerc · FRUniversité Paris Sciences et Lettres · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has allowed major advances in oncology in the past years, in particular with the development of immune checkpoint inhibitors, but the clinical benefits are still limited, particularly in colorectal cancer (CRC). Our scientific approach is based on the search for innovative immunotherapy with a final goal that aims to induce an effective antitumor immune response in CRC. Here, we focused on a multikinase inhibitor, H89. We carried out

Indexed as

Colonic NeoplasmsProtein Kinase InhibitorsAnimalsImmune Checkpoint InhibitorsImmunotherapyMiceTumor MicroenvironmentImmune Checkpoint InhibitorsProtein Kinase Inhibitorscolorectal cancerH89immunoprophylaxisimmunotherapykinase inhibitor

Identifiers

PMID35572581
PMCPMC9097540
OpenAlexW4285745324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.